N/%   Sample PAD SAD ADMS Statistics*     178 60/33.7 78/43.8 40/22.5   Age of drinking M 14.9 14.8 15.1 14.5 F2,173=0.3/ns   sd 4.7 5.4 4.8 3.5   Age of excessive alcohol use M 27.8 30 27.1 26.1 F2,171=1.9/ns   sd 9.6 10.7 10.7 8.5   Age of alcohol dependence M 36.4 38.3 36.5 33.2 F2,147=3.0/p<0.05a   sd 9.4 8.3 9.8 8.5   Alcohol consumption (week) M 90.9 81.5 89.1 108 F2,171=1.3/ns   sd 80 53 79.3 101.1   Alcoholism (years) M 20.3 21.1 22.3 15.1 F2,173=5.2/p<0.05b   sd 11.8 13.2 11.5 8.8   SADQ M 27 27.6 27.1 25.8 F2,163=0.3/ns   sd 12.9 13.4 13.3 11.8   Daily cigarette use M 25 0 25.2 24.7 F1,105=0.4/ns   sd 12 0 12.2 11.8   Age onset cigarette use M 15.4 0 15.8 14.7 F1,104=0.9/ns   sd 3.4 0 3.5 3   FTND M 5.7 0 5.8 5.5 F1,105=0.0/ns   sd 2.3 0 2.3 2.2   PFHA (%)   65 66.7 63.6 65.1 χ2=0.14 /ns DT (%)   23.8 22.8 24 25 χ2=0.11/ns Seizures (%)   22.8 19.3 23 27.5 χ2=0.90/ns Detox. (%)   42.2 38.6 47.4 37.5 χ2=1.52/ns

Table 1: Legend I: PAD – “Pure” alcohol dependents; ADS-alcohol dependent smokers; ADMS-alcohol dependents with the use of multiple substances; PFHA (positive family history of alcoholism); DT (Delirium Tremens); FTND-fagerström test for nicotine dependence; SADQseverity alcohol dependence questionnaire. Legend II: a: earlier age of alcohol dependence onset in ADMS when comparing to PAD. b: less years of alcoholism in ADMS when comparing to PAD and ADS.