Diagnosis Category Buprenorphine (N=51) N (%) Methadone (N=196) N (%) Risk Ratio (95% CI)
Routine care / social Events 35 (68.6) 150 (76.5) 0.90 (0.73, 1.10)
Well child visit 28 (54.9) 118 (60.2) 0.91 (0.69, 1.20)
Delayed immunizations 2 (3.9) 6 (3.1) 1.28 (0.27, 6.16)
Social Problems 7 (13.7) 37 (18.9) 0.73 (0.34, 1.53)
Hepatitis C Exposure 17 (33.3) 108 (55.1) 0.60 (0.40, 0.91)
Weight check 10 (19.6) 18 (9.2) 2.14 (1.05, 4.34)
Vaccination margin 4 (7.8) 21 (10.7) 0.73 (0.26, 2.04)
HIV Exposure 0 (0) 6 (3.1) -
Growth and feeding diagnoses 12 (23.5) 46 (23.5) 1.00 (0.58, 1.75)
Failure to thrive 4 (7.8) 10 (5.1) 1.54 (0.50, 4.70)
Weight loss/inadequate gain 2 (3.9) 3 (1.5) 2.56 (0.44, 14.93)
Obesity/overweight 1 (2.0) 12 (6.1) 0.32 (0.04, 2.41)
Feeding problem 3 (5.9) 10 (5.1) 1.15 (0.33, 4.04)
Short stature 0 (0) 5 (2.6) -
Weight gain 4 (7.9) 20 (10.2) 0.77 (0.27, 2.15)
Microcephaly 0 (0) 5 (2.6) -
Developmental delay diagnoses 6 (11.8) 38 (19.4) 0.61 (0.27, 1.36)
General delay, unspecified 1 (2.0) 17 (8.7) 0.23 (0.03, 1.66)
Language Delay/Speech problems 6 (11.8) 25 (12.8) 0.92 (0.40, 2.13)
Motor Delay 0 (0) 0 (0) -
Hypotonia 1 (2.0) 2 (1.0) 1.92 (0.18, 20.77)
Hypertonia 0 (0) 5 (2.6) -
Learning difficulties 0 (0) 2 (1.0) -
Pervasive developmental disorder 0 (0) 0 (0) -
Visual diagnoses 2 (3.9) 22 (11.2) 0.35 (0.08, 1.44)
Strabismus 0 (0) 14 (7.1) -
Visual impairment 2 (3.9) 4 (2.0) 1.92 (0.36, 10.20)
Nystagmus 0 (0) 2 (1.0) -
Other visual diagnosis 0 (0) 4 (2.0) -
Hearing diagnoses 0 (0) 4 (2.0) -
Behaviour/Attention/Sleep 4 (7.8) 22 (11.2) 0.70 (0.25, 1.94)
Behavioural problems 1 (2.0) 10 (5.1) 0.38 (0.05, 2.93)
Attentional problems 0 (0) 2 (1.0) -
Sleep disorders 3 (5.9) 4 (2.0) 2.88 (0.67, 12.47)
Seizures/staring spells 1 (2.0) 2 (1.0) 1.92 (0.18, 20.77)
Autism 0 (0) 6 (3.1) -
Anxiety disorder 0 (0) 3 (1.5) -
Table 2: Infant clinical events by in-utero exposure to prenatal opioid agonist treatment.