Dataset Num. of cases with/without a pattern Num. of controls with/without a pattern Unadjusted P value Adjusted P value Odds Ratio (Confidence Interval) Marker patterns
Alcohol Dependence (12 patterns) 71/207 37/268 3.19×10-5 0.007 2.48 (1.60-3.85) M5_C + D6_AA
89/181 57/247 1.00×10-4 0.013 2.11 (1.44-3.11) D4_AA + K4_TT
62/215 31/276 5.13×10-5 0.014 2.57 (1.61-4.09) M2_A + D6_AA
60/218 29/277 4.87×10-5 0.014 2.63 (1.63-4.23) M3_A + D6_AA
109/163 75/215 3.00×10-4 0.024 1.92 (1.34-2.74) D6_AA + K6_CC
76/200 45/259 2.00×10-4 0.03 2.19 (1.45-3.30) M7_G + D9_AA
46/232 19/285 8.25×10-5 0.032 2.97 (1.70-5.21) M7_AG + D6_AA
60/216 31/276 1.00×10-4 0.034 2.47 (1.55-3.95) M2_A + D7_TT
87/188 57/250 3.00×10-4 0.034 2.03 (1.38-2.98) M2_A + D9_AA
52/225 24/280 1.00×10-5 0.038 2.70 (1.61-4.51) M7_G + D7_TT
52/226 24/280 1.00×10-4 0.04 2.68 (1.60-4.49) M7_G + D6_AA
45/232 19/285 1.00×10-4 0.049 2.91 (1.66-5.11) M7_AG + D7_TT
Cocaine Dependence (4 patterns) 39/102 37/268 5.13×10-5 0.001 2.77 (1.67-4.59) M5_C + D6_AA
37/103 37/268 2.00×10-4 0.037 2.60 (1.56-4.33) M5_C + D7_TT
33/107 31/276 2.00×10-4 0.043 2.75 (1.60-4.71) M2_A + D7_TT
19/120 11/293 9.67×10-5 0.047 4.22 (1.95-9.13) M8_CC + K3_TT
Opioid Dependence (18 patterns) 33/44 57/249 7.74×10-6 0.0004 3.28 (1.92-5.60) M2_A + D9_AA
20/58 24/282 1.06×10-5 0.002 4.05 (2.10-7.82) M2_GA + D6_AA
22/56 30/275 2.45×10-5 0.005 3.60 (1.94-6.70) M11_CC + K3_TT
22/55 31/275 2.87×10-5 0.005 3.55 (1.88-6.46) M12_TT + K3_TT
30/47 55/250 8.25×10-5 0.005 2.90 (1.69-4.99) M3_A + D9_AA
13/63 11/292 1.70×10-5 0.006 5.48 (2.35-12.79) M8_CC + K3_TT
22/56 31/275 3.74×10-5 0.007 3.49 (1.88-6.46) M2_A + D6_AA
27/50 47/259 9.17×10-5 0.01 2.98 (1.70-5.22) M2_GA+ D9_AA
19/59 24/281 3.94×10-5 0.01 3.77 (1.94-7.33) M3_CA + D6_AA
18/60 22/284 4.15×10-5 0.012 3.87 (1.96-7.66) M13_GG + K3_TT
19/59 25/281 6.33×10-5 0.016 3.62 (1.87-7.00) M2_GA + D7_AA
20/58 28/278 8.70×10-5 0.02 3.42 (1.81-6.49) D4_AA + K3_TT
18/60 23/282 7.83×10-5 0.022 3.68 (1.87-7.24) M3_CA + D7_TT
26/51 46/259 2.00×10-4 0.023 2.87 (1.63-5.06) M3_CA+ D9_AA
21/57 31/275 1.00×10-4 0.024 3.27 (1.75-6.09) M2_A + D7_TT
18/60 24/282 1.00×10-4 0.034 3.52 (1.80-6.90) M9_CC + K3_TT
20/58 29/276 1.00×10-4 0.035 3.28 (1.74-6.20) M3_A + D6_AA
25/53 44/262 3.00×10-4 0.041 2.81 (1.58-4.98) M2_A + D4_AA
Dataset: genotype data of controls and alcohol, cocaine, or opioid dependent cases.
Table 2: Significant marker patterns identified in two-locus marker-based gene-gene interaction analyses.