Control Treated
Total pregnant mice 20 40
No. of pregnant mice successfully carrying to term, GD 19 (%) 20 (100%) 18 (35%)
No. of pregnant mice with complete fetal resorption (%) 0 19 (47.5%)
No. of pregnant mice with vaginal bleeding during pregnancy(%) 0 3 (2.56%)*
No. of implantation sites 168 86
Total live fetuses 166 77
No. of dead fetus (%) 0 2(2.56%)
No. of resorbed implantion site (%) 2(2.7%) 7(8.9%)
No. of growth retarded fetuses (%) 19(11.3%) 54(70.1%)
No. of fetus with birth defects (%) 0 3(3.91%)*
Litter size 6.5±1.2 4.53±0.99
Table 1: Zidovudine administration (50 mg/kg/day) from GD8 to GD 16 and outcome o pregnancy *ref 6.