A. Switched Memory B cell subset distribution (cells/ml)
Patient groups PPS14- (Unselected) Day 0 PPS14+ (Selected) Day 7 PPS23F- (Unselected) Day 0 PPS23F+ (Selected) Day 7
Group A (CD4>200) 624±200 1022±155  525±104   1215±196**
Group B  (CD4<200) 159±48 731±212* 162±28 1653±467*
  B. IgM Memory B cell subset distribution (cells/ml)
Patient groups PPS14- (Unselected) Day 0 PPS14+ (Selected) Day 7 PPS23F- (Unselected) Day 0 PPS23F+ (Selected) Day 7
Group A (CD4>200) 317±60    1109±142*** 331±47  1458±233***
Group B  (CD4<200) 184±56 1281±368* 239±64 1653±467**
  C. Naive B cell subset distribution (cells/ml)
Patient groups PPS14- (Unselected) Day 0 PPS14+ (Selected) Day 7 PPS23F- (Unselected) Day 0 PPS23F+ (Selected) Day 7
Group A (CD4>200) 1116±326 1503±235   524±101      1212±158***
Group B  (CD4<200) 675±220 555±135 635±205 907±250
Data are mean ± standard error of the mean. * indicates significant rise in the post vaccination (day7) levels compared to pre-vaccination (day 0) within a group. Cell counts of specific cell population in donor groups are reported as the average value of = [(percentage of specific cell population) * total lymphocytes/ml] for that group. Pre to post vaccination changes in a single group were compared using paired t-test and between groups were compared using analysis of co-variance (ANCOVA).*p<0.05, **p<0.01, ***p<0.001.
Table 5: Unselected (PPS-) versus PPS-selected (PPS+) CD19+ B cell subset numbers (cells/ml) in long term HAART cohort’s pre and 7 days post PPV23 revaccination.
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