Cardiovascular markers (change in regression outcome)
Inflammation biomarkers (change in log-transformed regression predictor) Isoprostane-to-Creatinine ratio Augmentation Index Reactive Hyperemia Index QTc RMSSD Triangular Index Low frequency variations High frequency variations Power Ratio Systolic blood pressure Diastolic blood pressure Heart rate
C-reactive protein 0.00, p=0.96 -2.22,
p=0.54
-0.09, p=0.07 1.35, p=0.74 -5.76, p=0.37 -1.32, p=0.18 5.60, p=0.65 -22.80, p=0.18 0.05, p=0.81 1.62, p=0.60 -0.09, p=0.97 3.43, p=0.23
Tumor necrosis factor-α receptor 1 -0.08, p=0.52 -6.22,
p=0.54
-0.26, p=0.03 9.62, p=0.31 -10.09, p=0.69 -2.13, p=0.41 12.78, p=0.70 -38.72, p=0.40 0.02, p=0.97 0.20, p=0.98 -3.98, p=0.38 14.10, p=0.06
Soluble CD163 0.02, p=0.86 -14.06, p=0.04 -0.11, p=0.17 2.71, p=0.68 -2.05, p=0.91 -1.75, p=0.34 28.46, p=0.16 1.86
p=0.95
0.33, p=0.23 5.19, p=0.30 2.34, p=0.46 9.44, p=0.06
Soluble CD14 -0.03, p=0.83 -15.37, p=0.25 -0.05, p=0.77 -4.08, p=0.73 11.25, p=0.76 0.41, p=0.91 9.91, p=0.79 -21.07, p=0.72 -0.03, p=0.96 -2.51, p=0.78 2.45, p=0.67 13.31, p=0.17
Models estimate the relationship between the change in log-transformed inflammation biomarker and change in cardiovascular marker using ordinary least squares regression, adjusted for baseline values.  Bold values represent statistically significant findings. Abbreviation: QTC: Corrected QT interval; RMSSD: Root Mean Square of the Successive Differences. Reactive hyperemia index is natural log transformed
Table 2: Linear models of the paired change in cardiovascular markers and inflammation biomarkers over 12 weeks of ART.
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