Figure 1: Safety assessment, showing maximum local reactogenicity A) and systemic reactogenicity, B) by treatment group. Subjects in control (C) groups 1-4 received group phosphate buffered saline. Subjects in treatment groups 1-3 (T1-T3) were Ad5 seronegative at baseline and received: T1- recombinant Ad35 (rAd35) prime and rAd5 boost; T2- three DNA priming injections boosted by rAd5; and T3- three DNA priming injections boosted by rAd35. Subjects in T4 were Ad5 seropositive at baseline and received three DNA priming injections boosted by rAd35. P values for comparisons of local and systemic reactogenicity were determined using the Kruskal-Wallis test.