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Table 1: Correlation between physicochemical properties and toxicities of local anesthetics. Concentrations of local anesthetics (in mM) leading to half-maximal cytotoxic effects (LD50) after 24 h of incubation were calculated by probit regression analysis of concentration-response relationship experiments in HL-60 cells. Values are mean + SD. Partition coefficients with H-octanol/buffer at pH 7.4 (logp) and ionization contents (pKa), unionized fraction at pH 7.4, protein binding, molecular weight of the local anesthetics, and relative experimentally effective anesthetic concentrations from C fibers of isolated rabbit vagus were used to calculate Spearman’s rank correlation coefficients. |