Hot plate baseline Hot plate 30 min Hot plate 60 min Hot plate 90 min Group C 7.24 ± 1.22 7.80 ± 1.50 7.38 ± 0.98 9.07 ± 2.10 Group ISO 7.78 ± 1.24 9.33 ± 1.09 9.28 ± 1.31 9.17 ± 2.60 Group N 8.78 ± 1.28 9.33 ± 1.34 9.25 ± 2.14 9.70 ± 2.80 Group L 8.70 ± 1.33 10.3 ± 2.10 20.52 ± 5.12▲ 27.75 ± 6.54■ Group L+N 7.86 ± 1.42 21.25 ± 3.4◆ 28.20 ± 5.30• 32.90 ± 8.57★ Data are means ± SD. ▲In Group L, compared to Group C (p= 0.006), Group ISO (p= 0.012), and Group N (p= 0.018), at 60 min. ■In Group L, compared to Group C (p= 0.001), Group ISO (p= 0.001), and Group N (p= 0.001) at 90 min. ◆In Group L+N, compared to Group C (p= 0.001), Group ISO (p= 0.001), Group N (p= 0.001), and Group L (p= 0.001) at 30 min. •In Group L+N, compared to Group C (p<0.001), Group ISO (p<0.001), Group N (p<0.001), and Group L (p= 0.001) at 60 min. ★In Group L+N compared to Group L (p= 0.007) at 90 min.

Table1: Changes in latency of hot plate test (seconds) at 30, 60, 90 minutes in groups.