Glutathione (mmol/g Hb) Catalase (k/g Hb) baseline value after painful stimulation baseline value after painful stimulation Group C 3.32±0.47 3.29 ±0.41 418.43±51.24 406.38±44.23 Group ISO 3.25±0.56 3.34±0.36 420.32±63.91 412.44 ±58.82 Group N 3.29±0.34 4.71±0.44 ▲ 416.74±48.63 589.38±54.83★ Group L 3.43±0.38 3.82±0.42■ 420.26±87.18 492.42 ±39.45• Group L+N 3.33±0.45 5.52±0.24◆ 421.34±75.96 687.36 ±62.75✯ Data are means ± SD ▲After painful stimulation, in Group N, compared to Group C (p=0.0022), Group ISO (p=0.0028) and Group L (p=0.032) for glutathione levels. ■After painful stimulation, in Group L+N, compared to Group C (p<0.0001), Group ISO (p<0.0001), Group L (p<0.0001) and Group N (p=0.041) in for glutathione levels. ◆After painful stimulation, in Group L, compared to Group C (p=0.043), Group ISO (p=0.042), for glutathione levels. ★After painful stimulation, in Group N, compared to Group C (p=0.0024), Group ISO (p=0.0019) and Group L (p=0.028) for catalase levels. •After painful stimulation, in Group L+N, compared to Group C (p<0.0001), Group ISO (p<0.0001) and Group L (p=0.005) for catalase levels. ✯After painful stimulation, in Group L, compared to Group C (p=0.024) and Group ISO (p=0.022) for catalase levels.

Table 3: Changes in glutathione and catalase levels before drugs administration and after painful stimulation.