Before rFVIIa Treatment After rFVIIa Treatment P-value
Blood loss (ml/kg/hr) 7.47 ± 1.53    
First 6 hr blood loss (ml/kg/hr) - 2.37 ± 0.67 0.001
Following 18 hr blood Loss
(ml/kg/hr)
- 1.08 ± 0.42 0.001
P-RBC (units) 11.25 ± 3.57 5.93 ± 1.70 0.001
Platelet (units) 11.77 ± 4.40 3.65 ± 1.42 0.001
FFP (units) 11.35 ± 4.15 3.86 ± 1.52 0.001
Cryoprecipitate (units) 10.16 ± 3.76 2.91 ± 2.11 0.001
PT (seconds) 11.05 ± 1.29 11.32 ± 1.49 0.244
INR 1.21 ± 0.18 1.25 ± 0.22 0.126
aPTT (seconds) 45.53 ± 9.81 41.25 ± 8.82 0.036
ACT(seconds) 138.19 ±16.15 136.60 ± 11.62 0.604
Platelet (x103/dl) 149.74 ± 44.51 154.65 ± 50.67 0.237
Fibrinogen (gm/l) 3.59 ± 0.49 3.94 ± 0.43 0.603
HB (g/dl) 9.66 ± 2.60 10.65 ± 1.73 0.211
rFVIIa Intraoperative (6 patients)      
Postoperative (37 patients)      
Dose (μg/kg) 93.72 ± 17.39      
P-RBC=packed- red blood cells, FFP = fresh frozen plazma, HB= heamoglobin, PT= prothrombin time, INR =international normalized ratio, aPTT =activated prothrombin time, rFVIIa = activated recombinant factor VII. Values are expressed as number, %, mean(SD)
Table 4: Blood loss, blood products transfusion and coagulation profiles before and after rFVII a