| Factors | Comments | Reference | 
      
        | Patient-related | DM | DM predisposes to RAO as shown in a large study of    predictors of RAO, using a regression model | 46. Zhou YJ, Zhao YX, Cao Z et    al. Zhonghua Yi Xue Za Zhi 2007; 87: 1531-4.  | 
      
        | Female gender | RAO is more frequent in females as shown in a    large study of predictors of RAO, using a regression model | 46. Zhou YJ, Zhao YX, Cao Z et    al. Zhonghua Yi Xue Za Zhi 2007; 87: 1531-4.  | 
      
        | Low BMI | Low body weight patients are at significantly    higher risk of RAO | 51. Pancholy SB. Am J Cardiol    2009; 104: 1083-5.  | 
      
        | Procedural-related | Anticoagulation | Heparin was shown to be crucial in reducing    incidence of RAO, with a dose-dependent beneficial effect. No difference in    magnitude of effect between IV and IA route of administration | 45. Lefevre T, Thebault B,    Spaulding C et al. Eur Heart J 1995; 16: 293.46. Zhou YJ, Zhao YX, Cao Z et    al. Zhonghua Yi Xue Za Zhi 2007; 87: 1531-4
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        | Size of sheath and catheters | Ratio of sheath outer diameter to inner diameter    of radial artery is indirectly proportionate to incidence of RAO. The bigger    lower the ration (i.e. the bigger the sheath), the higher the incidence of    RAO. | 46. Zhou YJ, Zhao YX, Cao Z et    al. Zhonghua Yi Xue Za Zhi 2007; 87: 1531-452. Saito S, Ikei H, Hosokawa G,    Tanaka S. Catheter Cardiovasc Interv 1999; 46: 173-8
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        | Successive cannulation | Incidence of TRA dropouts increases as successive    punctures were performed due to narrowing and occlusion of the radial artery,    probably as a function of repeated punctures | 53. Sakai H, Ikeda S, Harada T et    al. Catheter Cardiovasc Interv 2001; 54: 204-8.  | 
      
        | Occlusive hemostasis | Use of occlusive hemostasis, and duration of    radial artery compression post-procedure is an independent predictor of RAO.    Patent hemostasis reduces incidence of RAO. | 46. Zhou YJ, Zhao YX, Cao Z et    al. Zhonghua Yi Xue Za Zhi 2007; 87: 1531-4.51. Pancholy SB. Am J Cardiol    2009; 104: 1083-5.
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