Factors

Comments

Reference

Patient-related

DM

DM predisposes to RAO as shown in a large study of predictors of RAO, using a regression model

46. Zhou YJ, Zhao YX, Cao Z et al. Zhonghua Yi Xue Za Zhi 2007; 87: 1531-4.

Female gender

RAO is more frequent in females as shown in a large study of predictors of RAO, using a regression model

46. Zhou YJ, Zhao YX, Cao Z et al. Zhonghua Yi Xue Za Zhi 2007; 87: 1531-4.

Low BMI

Low body weight patients are at significantly higher risk of RAO

51. Pancholy SB. Am J Cardiol 2009; 104: 1083-5.

Procedural-related

Anticoagulation

Heparin was shown to be crucial in reducing incidence of RAO, with a dose-dependent beneficial effect. No difference in magnitude of effect between IV and IA route of administration

45. Lefevre T, Thebault B, Spaulding C et al. Eur Heart J 1995; 16: 293.
46. Zhou YJ, Zhao YX, Cao Z et al. Zhonghua Yi Xue Za Zhi 2007; 87: 1531-4

Size of sheath and catheters

Ratio of sheath outer diameter to inner diameter of radial artery is indirectly proportionate to incidence of RAO. The bigger lower the ration (i.e. the bigger the sheath), the higher the incidence of RAO.

46. Zhou YJ, Zhao YX, Cao Z et al. Zhonghua Yi Xue Za Zhi 2007; 87: 1531-4
52. Saito S, Ikei H, Hosokawa G, Tanaka S. Catheter Cardiovasc Interv 1999; 46: 173-8

Successive cannulation

Incidence of TRA dropouts increases as successive punctures were performed due to narrowing and occlusion of the radial artery, probably as a function of repeated punctures

53. Sakai H, Ikeda S, Harada T et al. Catheter Cardiovasc Interv 2001; 54: 204-8.

Occlusive hemostasis

Use of occlusive hemostasis, and duration of radial artery compression post-procedure is an independent predictor of RAO. Patent hemostasis reduces incidence of RAO.

46. Zhou YJ, Zhao YX, Cao Z et al. Zhonghua Yi Xue Za Zhi 2007; 87: 1531-4.
51. Pancholy SB. Am J Cardiol 2009; 104: 1083-5.

Table 2: Predisposing factors to Radial Artery Occlusion.