Median (Q1,Q3)

AEP Group (n=16)

Control Group (n=16)

Two sided (p-value*)

IL-6 (Pre)
IL-6 (2h post)
IL-6 (20 h post)
Within group
Pre - 2  h post
Pre - 20 h post

0.50 (0.09-1.10)
8.06 (3.95-13.69)
7.89 (5.74-13.70)

<0.001
0.001

0.36 (0.10-1.32)
7.54 (4.85-16.28)
7.65 (3.06-15.88)

0.001
0.001

0.850
0.546
0.970


*

H-CRP (Pre)
H-CRP (2h post)
H-CRP (20 h post)
Within group
Pre - 2  h post
Pre - 20 h post

2.32 (0.75-4.59)
1.59 (0.62-4.22)
11.75 (7.18-23.58)

0.023
0.001

1.55 (0.63-3.31)
1.25 (0.55-1.87)
12.43 (3.47-22.74)

0.026
0.001

0.366
0.407
0.624


*

IL-10 (Pre)
IL-10 (2h post)
IL-10 (20 h post)
Within group
Pre - 2  h post
Pre - 20 h post

2.56 (1.60-3.28)
2.75 (2.01-8.02)
3.60 (2.24-4.57)

0.950
0.430

1.81 (1.37-3.17)
5.25 (2.29-6.48)
3.42 (1.95-5.52)

0.003
0.005

0.571
0.366
0.985


*

IL-8 (Pre)
IL-8 (2h post)
IL-8 (20 h post)

6.45 (5.20-9.04)
11.28 (6.77-19.14)
9.53 (6.76-11.23)

5.83 (4.93-10.90)
9.36 (7.05-11.36)
7.21 (5.12-13.40)

0.792
0.291
0.346

TNF-Alfa(Pre)
TNF-Alfa (2h post)
TNF-Alfa (20 h post)

5.6 (4.44-6.88)
5.04 (4.29-5.78)
5.28 (4.03-6.80)

5.94 (4.91-9.20)
5.42 (4.10-8.57)
6.29 (3.32-9.84)

0.291
0.366
0.851

Mann Whitney U-test between groups. * Wilcoxon test within groups
Table 5: Cytokine, TNF-alfa and H-CRP