Variable

Normal Physiology

Cardiac Transplant

One Ventricle Physiology

P-value

Baseline (sevoflurane only)
Heart Rate

120±14

92±11

91±17

<0.0001
Systolic Pressure

84±14

85±11

87±9

0.8002
Diastolic Pressure

43±7

47±2

45±6

0.0048
Mean Pressure

58±7

60±6

60±6

0.4824
Bispectral Index

45±9

40±9

40±6

0.1566
Oxygen Saturation

97±0

97±2

89±4

0.3031

Steady-state (sevoflurane+dexmedetomidine)
Heart Rate

105±12

78±12

91±17

<0.0001
Systolic Pressure

97±19

100±10

103±21

0.6511
Diastolic Pressure

53±13

56±3

55±18

0.2893
Mean Pressure

72±13

70±11

71±22

0.6792
Bispectral Index

48±12

45±13

35±7

0.5167
Oxygen Saturation

98±2

98±2

91±6

0.8465
*P values reflect the comparisons between normal physiology and cardiac transplantation groups at respective time points
Table 3: Mean±SD hemodynamic variables at baseline and during steady-state (sevoflurane+dexmedetomidine).