Cardiac dysfunction in patients suffering from cirrhosis characterized by impaired contractile responsiveness to stress and/or altered diastolic relaxation with associated electrophysiological abnormalities in the absence of other known cardiac disease.
Diagnostic criteria:
Systolic dysfunction
- Blunted increase in cardiac output with exercise, volume challenge or pharmacological stimuli
- Resting EF <55%
Diastolic dysfunction
- E/A < 1
- Prolonged deceleration time (> 200 msec)
- Prolonged isovolumetric relaxation time (< 80 msec)
Supportive criteria
- Electrophysiological abnormalities
- Chronotropic incompetence
- Electromechanical uncoupling
- Prolonged QTc interval
- Enlarged left atrium
- Increased myocardial mass
- Increased BNP, pro-BNP
- Increased Troponin I
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