Drug* |
Mean NNT† |
95% CI |
Diclofenac (100 mg PO) |
1.9 |
1.6 - 2.2 |
Rofecoxib (50 mg PO) |
1.9 |
1.8 - 2.1 |
Codein (60 mg) + acetaminophen (1000 mg PO) |
2.2 |
1.7 – 2.9 |
Diclofenac (50 mg PO) |
2.3 |
2.0 – 2.7 |
Ibuprofen (600 mg PO) |
2.4 |
1.9 – 3.3 |
Oxycodone (15 mg PO) |
2.4 |
1.5 – 4.9 |
Oxycodone (5 mg) + acetaminophen (325 mg PO) |
2.5 |
2.0 – 3.2 |
Ketorolac (10 mg PO) |
2.6 |
2.3 – 3.2 |
Meperidine (100 mg IM) |
2.9 |
2.6 – 3.6 |
Morphine (10 mg IM) |
2.9 |
2.6 – 3.6 |
Ketorolac (30 mg IM) |
3.4 |
2.5 – 4.9 |
Acetaminophen (1000 mg PO) |
3.8 |
3.4 – 4.4 |
Aspirin (1000 mg PO) |
4.0 |
3.2 – 5.4 |
Codeine (60 mg) + acetaminophen (600 to 650 mg PO) |
4.2 |
3.4 – 5.3 |
Aspirin (600 to 650 mg PO) |
4.4 |
4.0 – 4.9 |
Dextropropoxyphene (65 mg) + acetaminophen
(650 mg PO) |
4.4 |
3.5 – 5.6 |
Acetaminophen (600 to 650 mg PO) |
4.6 |
3.9 – 5.5 |
Tramadol (100 mg PO) |
4.8 |
3.8 – 6.1 |
Dextropropoxyphene (65 mg PO) |
7.7 |
4.6 – 22 |
Dihydrocodeine (30 mg PO) |
8.1 |
4.1 – 540 |
Codeine (60 mg PO) |
16.7 |
11.0 – 48.0 |
CI, confidence interval; IM, intramuscular; NNT, number needed to treat; PO, oral
route.