| 
      
        |  | Left    shift (>affinity for O2) | Right    shift (<affinity for O2) |  
        | Temperature | Decrease | Increase |  
        | 2,3-diphosphoglycerate(2.3-GPD) | Decrease | Increase |  
        | p(CO2) | Decrease | Increase |  
        | p(CO) | Increase | Decrease |  
        | pH (Bohr effect) | Increase    (alkalosis) | Decrease    (acidosis) |  
        | Type    of hemoglobin | Fetal hemoglobin | Adult    hemoglobin |  |