Reference Total number of patients Prospective study Dose Results
Neuhaus et al.1989(20) 20 No 2 million KIU Reduction in RBC,FFP and surgical time
Mallett et al. 1990(19) 24 No 2 million KIU followed by 500.000 KIU/hour during surgery: 70.000 KIU each RBC  
Cottam et al.1991(21) 8 No 2 million KIU and followed by 500.000 KIU/hour, 50.000 KIU given to each unit of RBC Reduce t-PA production and increase alpha-2 antiplasmin
Grosse et al.1991(22) 50 No 2 million KIU followed by 500.000 during surgery Reduce fibrinolysis(measured by TEG),RBC,FFP, and platelets
Himmelreich et al.1992(23) 23 No 500.000 KIU bolus before, during and after reperfusion Smaller increase in t-PA in comparison to other studies
Soilleux et al., 1995(24) 189 Yes 2 million KIU load plus 500.000 KIU/hour infusion or 500.000 KIU load plus 150.000 No differences in RBC in the high and low dose aprotinin group
Scudamore et al., 1995(25) 66 No 1 million KIU bolus plus 500.000 KIU/hour infusion Reduction in Cryo,FFP, RBC in the aprotinin but not in the EACA group
Milroy et al.,1995(26) 52 Yes Load 280 mg pus 70 mg/hour infusion,additional 140 mg to bypass Greater SVRI,O2 extraction ratio and less CI,DO2 5 minutes after reperfusion
Marcel et al.,1996(27) 44 Yes 200.000 KIU/hour infusion Reduce FFP,Cryo but not RBC or platelets,less EACA rescue
Garcia-(28)Huete,1997 80 Yes 2 million KIU plus 500.000/hour No difference in EBL, blood products
Porte et al.,2000(29) 137 Yes High: 2 million KIU load plus 1 million/hour plus 1 million 30 min before reperfusion,low: 2 million plus 500.000/hour 60% and 44%EBL,37% and 20% RBC reduction in high and regular dose groups, compared to placebo
Findlay et al.,2001(70) 63 Yes 1 million KIU load plus 250.000 KIU/hour Reduce RBC requirements but not FFP, platelets or cryo
Molenaar et al., 2001 93 Yes High: 2 million load plus 1 million/hour plus 1 million before reperfusion,low:2 million + 500.000 KIU/hour No renal toxicity
Molenaar et al.,2001 137 Yes High: 2 million load plus 1 million/hour plus 1 million 30 min before reperfusion,low:2 million + 500.000KIU/hour Better 1- month graft survival
Molenaar et al.,2001 67 Yes High and low regimen comparison Less epinephrine use in high or low dose group
Rentoul et al.,2003(71) 24 No 15.000 KIU/kg load plus 5000/hour infusion Reduce RBC and FFP requirements
Findlay and (72)Kufner,2003 63 Yes 1 million KIU load plus 250.000KIU/hour Less vasoactive infusion in the aprotinin group
Warnaar et al.,2007 1043 No 2 million KIU load plus 500.000 KIU/hour 2 time higher risk of severe renal dysfunction within the first week
Tranexamic acid(TA)        
Carlier et al.,1987(49) 33 No 15 mg/kg for 8 hours 41%of patients with normal ECLT
Boylan et al.,1996(52) 45 Yes 40 mg/kg/hour uo to 40 g Reduced EBL,plasma,platelet and cryo; no RBC
Kasper et al.,1997(53) 32 Yes 2mg/kg/hour TA decreased fibrinolysis and need for EACA rescue but not transfusion requirements
Epsilon aminocaproic acid (EACA)        
Kaulla1966(57) 3 No Not reported Patients died of severe hemorrhage or thrombolic complication
Kang et al.1987(60) 20 No 1 gm fibrinolysis’s improvement
Scudamore et al. 1995 (13) No No Non reported No effects on transfusion
Table 1: Antifibrinolytics in Orthotopic liver transplantation.