Parameter Lidocaine Diltiazem Esmolol PI PII PIII PIV
SBP (mmHg) 131.2 ± 1.79 128.2 ± 1.45 126.3 ± 1.37 0.0758 0.1853 0.0302 0.3428
DBP (mmHg) 86.00 ± 0.88 83.50 ± 0.73 79.03 ± 0.93 P<0.0001 0.0318 P<0.0001 0.0003
HR (per min) 97.80 ± 1.40 87.70 ± 1.41 88.20 ± 1.39 P<0.0001 P<0.0001 P<0.0001 0.8013
MAP (mmHg) 101.1 ± 0.76 98.38 ± 0.73 94.77 ± 0.77 P<0.0001 0.0124 P<0.0001 0.001
RPP 12840 ± 261.7 11270 ± 257.9 11140 ± 221.5 P<0.0001 P<0.0001 P<0.0001 0.713
Data are presented as means ± SEM, and p value. ANOVA with repeated measures was used to compare the changes in SBP, DBP, HR, MAP and RPP values. Bonferroni’s multiple comparison tests were used to make intragroup comparisons. Comparison PI-L, D&E, PII-L&D, PIII-L&E, PIV-D&E
Table 8: Change in haemodynamic variables in the study groups at 5 min with intragroup comparison