Tranexamic Acid N = 70 No Tranexamic Acid N = 160 P Value Total IV Anesthesia # 68 (97%) 99 (62%) < 0.001 Balanced Anesthesia Technique # 2 (3%) 61 (38%) < 0.001 Intrathecal Opioids # of patients 60 (86%) 142 (89%) 0.67  Deliberate Hypotension # 21 (30%) 64 (40%) 0.19 Inotropic Medications # 35 (50%) 17 (11%) < 0.001 Methylprednisolone # 2 (3%) 0 0.09 Intra-operative extraction of whole blood #  28 (40%) 33 (21%) 0.004 Volume of intra-operative extraction of  whole blood ml 273 (250, 335) N = 28 350 (250, 450) N = 33 0.009

Table 2: Intra-operative Events Data (not normally distributed) is presented as median (interquartile range) and is analyzed by Wilcoxon Rank Sum test. Categorical data is presented as number and percentage of group and is analyzed by Pearson chi-squared test with Yates continuity correction or Fischer exact test when 6 or less outcomes in a group. *Some patients received separately morphine or sufentanyl, some received both.