First author and year

Patient age(years)

Surgery type

D/C (No. of patients)

Intervention

Main outcome measures

New Jadad score

Dexmedetomidine group

Control group

O¨zcengiz [3] 2011

Erdil [4] 2009

Guler [5] 2005

Jia-Yao [6] 2013
Masami [7] 2010

Shukry [8] 2005

Mauricio E [9]
2004
Nidhi [10] 2013

Qing-tao [11] 2012

Liu [12] 2012

Zhang [13] 2010

Fang [14] 2010

Wen [15] 2012

Cao [16] 2012

Zhu [17] 2011

Zhu [18] 2012

Du [19] 2012

Gan [20] 2011

Xue [21] 2011

Jia [22] 2012

Jin [23] 2011

Zhong [24] 2012

Chen [25] 2012

Wei [26] 2012

Huang [27] 2012

Huang [28] 2011

Zhao [29] 2012

3~9

2~7

3~7

2~7
1~9

1~10

1~10

8~12

5~13

3~11

2~8

3~10

3~11

3~6

3~8

3~8

3~9

4~7

3~9

2~7

3~12

4~10

2~8

3~7

1~3

5~8

2~8

esophageal dilatation procedures
adenoidectomy

adenotonsillectomy

strabismus surgery same-day surgery or over-night stay surgery
outpatient surgical
procedures
Inguinal hernia repair and circumcision
spinal dysraphism

tonsillectomy

not mention

Lower abdominal surgery

Oral and ENT surgery

Oral and ENT surgery

High ligation of the hernia sac and circumcision
adenoidectomy

Laryngeal papilloma resection
Inguinal hernia repair and circumcision
ENT surgery

Oral, Ophthalmologic, abdominal surgery
adenoidectomy

Ophthalmologic operation

tonsillectomy

High ligation of the processus vaginalis
Inguinal hernia repair

cleft lip and cleft palate repair
Hypospadias and ENT surgery
High ligation of the hernia sac and Orchidopexy

25/25

30/30

30/30

27/24
39/42

23/23

60/30

18/18

80/40

42/21

40/20

30/30

30/30

40/20

40/40

30/30

28/28

150/150

40/40

30/30

40/40

40/40

15/15

46/23

15/15

30/30

20/20

DEX 2.5 μg/kg, given orally

DEX 0.5 μg/kg IV after tracheal intubation
DEX 0.5 μg/kg IV,5 min before the end of surgery
DEX 1 μg/kg, IV
DEX 0.3 μg/kg IV over 10 min
after anesthetic induction
A continuous perioperative infusion of 0.2 μg/kg/h DEX
DEX 0.15 μg/kg OR 0.3 μg/kg IV after anesthetic induction
loading dose: DEX 1 μg/kg,0.5 μg/kg/h to maintain
loading dose: DEX 0.5 μg/kg OR 1 μg/kg IV over 10 minutes DEX 0.2 μg/kg OR 0.4 μg/kg IV before the end of surgery
DEX 0.3 μg/kg OR 0.5 μg/kg IV after the start of surgery
DEX 0.5 μg/kg IV before the surgery
DEX 0.5 μg/kg IV before the surgery
DEX 0.5 μg/kg OR 0.7 μg/kg,iv

DEX 0.5 μg/kg IV before anesthesia induction
DEX 0.5 μg/kg IV before anesthesia induction
DEX 1 μg/kg IV after the start of surgery
DEX 0.5 μg/kg IV before anesthesia induction
DEX 0.5 μg/kg IV after the start of surgery
loading dose: DEX 1 μg/kg,1 μg/kg/h to maintain
DEX 1 μg/kg IV after tracheal intubation
loading dose: DEX 0.1 μg/kg, and 0.3 μg/kg/h to maintain
DEX 1 μg/kg IV before anesthesia induction
DEX 0.15 μg/kg OR 0.3 μg/kg IV before the surgery
DEX 1 μg/kg IV, 30 min before the end of surgery
DEX 0.2 μg/kg IV, 30 min before the end of surgery DEX 1 μg/kg, iv

saline

saline

placebo

saline
saline

saline

saline

saline

lactated Ringer’s saline

saline

saline

saline

saline

saline

saline

saline

saline

saline

saline

saline

saline

saline

saline

saline

saline

saline

①②⑤⑥

①②④⑤⑥

②③⑤⑥
③⑤⑥

②③⑤⑥

①③⑤

①②⑤⑥

①②③⑤⑥

④⑤⑥

②⑤⑥

①⑤⑥

①②③④⑤⑥

①②③④⑤⑥

①⑤

②⑤

②⑤

①②⑤⑥

①③⑤⑥

①②⑤⑥

②③⑤⑥

①⑤

①⑤

①②⑤

①②⑤⑥

6

6

6

7
6

7

6

7

7

1

1

1

1

1

2

2

1

2

1

6

1

2

2

1

1

1

1


Note: ① recovery time ② extubation time ③ discharge time ④ occurrence of bucking ⑤ emergence agitation or agitation score ⑥ other adverse events
Table 1: Characteristics of included studies and Jadad score.