Measure Placebo (n = 31) P150 (n = 28) Estimated between-group difference 95% confidence interval p-value Intraoperative Fentanyl (mcg) 193 ± 56 178 ± 69 14.88 ± 16.31 -17.79 to 47.56 0.36 PACU Morphine (mg) 1.0 [0.0, 8.0] 3.5 [0.5, 6.8] -0.67 ± 1.06 -2.79 to 1.45 0.53 2-hour Sedation* 2 (2–3) 2 (2–2) – – 0.36 48-hour Patient Satisfaction 10 (5–10) 10 (7–10) 0.04 ± 0.26 -0.47 to 0.56 0.86

Table 3: Outcome Data by Group Allocation, Data presented as mean ± SD, median [IQR], or median (Range), Sedation scores analyzed by Mann Whitney U-test, *Modified Ramsay: 2 = patient cooperative, oriented, and tranquil.