| PK
Parameters |
Propofol[5,6] |
Remifentanil[1-4] |
Fentanyl [7] |
| Estimate |
CV (%) |
Estimate |
CV (%) |
Estimate |
| V1 (L) |
4.27 |
4.04 |
5.1 - 0.0201*(A-40) + .072*(lbm-55) |
26 |
0.105*M |
| V2 (L) |
18.9
-.391*(A-53) |
0.9 |
9.82 - .0811*(A-40) + .108*(lbm-55) |
29 |
0.446*M |
| V3 (L) |
238 |
14.35 |
5.42 |
66 |
3.37*M |
| CL1 (L/min) |
1.89
+.0456*(M-77)
-.0681*(lbm-59) +.0264*(H-177) |
10.05 |
2.6 - .0162*(A-40) + .0191*(lbm-55) |
14 |
0.00838*M |
| CL2 (L/min) |
1.29-.024*(A-53) |
0.9 |
2.05 - .0301*(A-40) |
36 |
0.0474*M |
| CL3 (L/min) |
.836 |
11.79 |
.076 - .00113*(A-40) |
41 |
0.0199*M |
| Ke0 (min-1) |
.456 |
42 |
.595 - .007*(A-40) |
68 |
0.15 |
V is the compartment volume in liters; CL is the clearance from that volume in liters per minute. M is the mass of the patient in kg, H is the height of the patient in cm, A is
the age of the patient in years, and lbm is the lean body mass. CV is the coefficient of variation for the parameter estimate. Ke0 is the elimination rate constant from the
effect site to outside the body. * indicates multiplication. |
