Clinical Interest Time Indicator Propofol (mcg/ml) Remifentnail (ng/ml) Fentanyl (ng/ml)
Laryngoscopy L 7.2 (1.5) 1.1 (0.4) 2.8 (0.9)
Skin Incision S 2.7 (0.4) 5.3 (1.0) 1.2 (0.3)
Emergence E 1.6 (0.4) 2.8 (0.9) 1.9 (0.7)
PACU P 0.6 (0.1) 0.3 (0.3) 1.0 (0.4)
The drug effect site concentration mean (standard deviation) at clinical points of interest for simulated dosing scheme as described in the methods. The clinical points of interest are the times for induction, skin incision, re-emergence, and postanesthesia care unit (PACU) arrival. The time indicators for each of the clinical interest points are shown in figure 1.
Table 4: Mean and (standard deviation) of the drug effect site concentration at clinical time points of interest for selected response surface models as presented in Figure 1.