| Clinical Interest |
Time Indicator |
Laryn |
Resp |
Pain |
IVD |
| Laryngoscopy |
L |
0.99
[0.70 – 1.0] |
1.0
[0.98-1.0] |
1.0
[1.0-1.0] |
|
| Skin Incision |
S |
|
0.99
[0.93-1.0] |
1.0
[1.0-1.0] |
|
| Emergence |
E |
|
0.87
[0.25-1] |
0.99
[0.91-1.0] |
|
| PACU |
P |
|
0
[0-0.08] |
0.001
[0-0.14] |
0.10
[0.01-0.43] |
The pharmacodynamic response probability intervals of the variability at clinical
points of interest are the median and inter-quartile ranges for the response to
laryngoscopy (Laryn), return of responsiveness (Resp), response to moderate pain
(Pain), and intolerable ventilatory depression (IVD). The clinical points of interest
are the times for induction, skin incision, re-emergence, and post-anesthesia care
unit (PACU) arrival. The clinical time points in terms of minutes from the beginning
of the 90 minute anesthetic simulation are 2, 15, 95, and 120 respectively. The
time indicators for each of the clinical interest points are shown in figure 3. Only the
stimuli for relevant points of interest are shown in the table. |
