Propofol (mcg/kg/min)
80 100 120
Fentanyl (mcg/kg) 1 10 (4) 11 (4) 12 (4)
2 12 (5) 13 (5) 15 (5)
3 15 (6) 16 (6) 17 (7)
Data are presented as the mean (standard deviation) time (in minutes) from termination of the propofol and remifentanil infusions to 50% intolerable ventilator depression (IVD) for each dosing scheme. The remifentanil infusion was held constant at 0.2 mcg/kg/min. A difference of 3 minutes was considered to be of clinical significance.
Table 8: Duration of intolerable ventilator depression (IVD) following termination of the anesthetic.