| |
|
|
|
|
VRSawake |
|
p values |
|
VRSd1A |
|
p values |
|
PCAmg.h-1 |
|
p values |
|
| Gene |
SNP |
Genotype |
Count |
% |
(IQR) |
Addit. |
Dom. |
Rec. |
(IQR) |
Addit. |
Dom. |
Rec. |
(IQR) |
Addit. |
Dom. |
Rec. |
| ABCB1 |
C3435T |
C/C |
37 |
27.2 |
4 (0-8) |
0.76 |
0.63 |
0.81 |
3 (1-5) |
0.35 |
0.23 |
0.25 |
0.77 (0.2-1.5) |
0.09 |
0.03 |
0.23 |
| |
|
C/T |
63 |
46.3 |
5 (0-8) |
|
|
|
3 (1-5) |
|
|
|
0.9 (1-1.9) |
|
|
|
| |
|
T/T |
36 |
26.5 |
4 (0-8) |
|
|
|
3 (0.8-4) |
|
|
|
0.11 (0-0.52) |
|
|
|
| |
T1236C |
T/T |
28 |
22.6 |
4 (0-8) |
0.35 |
0.67 |
0.28 |
3 (5) |
0.22 |
0.09 |
0.56 |
0.88 (0.11-2) |
0.8 |
0.7 |
0.78 |
| |
|
C/T |
62 |
50.0 |
5 (0-8) |
|
|
|
3 (1-5) |
|
|
|
0.69 (0-1.46) |
|
|
|
| |
|
C/C |
34 |
27.4 |
4 (0-8) |
|
|
|
4 (2-6) |
|
|
|
0.23 (0-1.23) |
|
|
|
| COMT |
Val158Met |
G/G |
34 |
25.4 |
5 (0-8) |
0.35 |
0.51 |
0.42 |
3 (1-3.3) |
0.97 |
0.89 |
0.92 |
0.59 (0.12-2.1) |
0.15 |
0.72 |
0.05 |
| |
|
G/A |
48 |
35.8 |
3 (0-6) |
|
|
|
3 (2-5) |
|
|
|
0.66 (0-1.3) |
|
|
|
| |
|
A/A |
52 |
38.8 |
5 (0-8) |
|
|
|
4 (1-4.5) |
|
|
|
0.34 (0-1.66) |
|
|
|
| CYP3A4 |
C20230T |
A/A |
9 |
6.6 |
5 (0-7) |
0.17 |
0.88 |
0.26 |
2 (0-3.5) |
0.78 |
0.91 |
0.61 |
0.26(0-1.5) |
0.92 |
0.61 |
0.99 |
| |
|
A/G |
38 |
27.7 |
3 (0-6) |
|
|
|
4 (2-5) |
|
|
|
0.715(0-1.5) |
|
|
|
| |
|
G/G |
90 |
65.7 |
4 (0-8) |
|
|
|
3 (1-5) |
|
|
|
0.55 (0.06-1.54) |
|
|
|
| CYP3A5 |
A6986G |
A/A |
5 |
3.7 |
0 (0-3) |
0.57 |
0.18 |
0.32 |
0 (0-2) |
0.25 |
0.23 |
0.06 |
0 (0-1.32) |
0.33 |
0.24 |
0.38 |
| |
|
G/A |
26 |
19.1 |
0 (0-6) |
|
|
|
2 (1-4.5) |
|
|
|
0.09 (0-1.32) |
|
|
|
| |
|
G/G |
105 |
77.2 |
5 (0-8) |
|
|
|
3 (2-5) |
|
|
|
0.66 (0.1-1.57) |
|
|
|
| NBEA |
A11771G |
G/G |
1 |
0.9 |
5 |
0.22 |
0.72 |
0.43 |
1 |
0.93 |
0.88 |
0.46 |
0.39 |
0.73 |
0.46 |
0.75 |
| |
|
G/A |
27 |
24.3 |
4 (0-8) |
|
|
|
3 (1-5.5) |
|
|
|
0.38 (0-1.36) |
|
|
|
| |
|
A/A |
83 |
74.8 |
5 (0-8) |
|
|
|
3(2-3) |
|
|
|
0.55 (0.1-1.45) |
|
|
|
| OPRM1 |
A118G |
G/G |
3 |
2.2 |
0 (0-8) |
0.85 |
0.69 |
0.95 |
3 (2-4) |
0.16 |
0.09 |
0.83 |
0.98 (0.37-1.2) |
0.62 |
0.37 |
0.95 |
| |
|
A/G |
31 |
22.6 |
5 (0-8) |
|
|
|
3 (1-5) |
|
|
|
0.77 (0-1.64) |
|
|
|
| |
|
A/A |
103 |
75.2 |
4 (0-7) |
|
|
|
3 (1-5) |
|
|
|
0.49 (0-1.45) |
|
|
|
| |
IVS2-691 |
G/G |
40 |
29.2 |
2 (0-5) |
0.11 |
0.07 |
0.09 |
2 (0-4) |
0.68 |
0.74 |
0.35 |
0.24 (0-1.26) |
0.15 |
0.63 |
0.04 |
| |
|
G/C |
59 |
43.1 |
5 (0-8) |
|
|
|
4 (2-5) |
|
|
|
0.72 (0-1.87) |
|
|
|
| |
|
C/C |
38 |
27.7 |
5 (0-8) |
|
|
|
3 (1-4) |
|
|
|
0.77 (0.06-1.45) |
|
|
|
| KCNJ6 |
A1032G |
A/A |
14 |
9.9 |
4 (0-6) |
0.78 |
0.66 |
0.5 |
3 (1-5) |
0.13 |
0.04 |
0.97 |
0.23 (0-1.59) |
0.5 |
0.51 |
0.58 |
| |
|
A/G |
58 |
41.1 |
4 (0-8) |
|
|
|
3 (1-4) |
|
|
|
0.6 (0-1.53) |
|
|
|
| |
|
G/G |
69 |
48.9 |
5 (0-8) |
|
|
|
3 (2-5) |
|
|
|
0.52 (0.18-1.44) |
|
|
|
| |
G-1250A |
G/G |
20 |
14.6 |
5 (0-8) |
0.2 |
0.07 |
0.55 |
1 (0-4) |
0.1 |
0.27 |
0.2 |
0.1 (0-1) |
0.49 |
0.59 |
0.27 |
| |
|
G/A |
67 |
48.9 |
5 (0-8) |
|
|
|
3 (2-5) |
|
|
|
0.8 (0.12-1.57) |
|
|
|
| |
|
A/A |
50 |
36.5 |
3 (0-7) |
|
|
|
3 (1-5) |
|
|
|
0.38 (0-1.5) |
|
|
|
| KCNS1 |
Ile489Val |
G/G |
24 |
18.8 |
5 (0-8) |
0.54 |
0.29 |
0.58 |
3 (1-4) |
0.22 |
0.25 |
0.38 |
0.58 (0.12-1.53) |
0.29 |
0.28 |
0.49 |
| |
|
A/G |
58 |
45.3 |
5 (0-8) |
|
|
|
3 (2-4) |
|
|
|
0.69 (0.05-1.65) |
|
|
|
| |
|
A/A |
46 |
35.9 |
3 (0-6) |
|
|
|
3 (1-5) |
|
|
|
0.22 (0-1.22) |
|
|
|
| SCN9a |
Arg1150Trp |
A/A |
0 |
0.0 |
n/a |
0.37 |
0.37 |
n/a |
n/a |
0.28 |
0.28 |
n/a |
n/a |
0.06 |
0.06 |
n/a |
| |
|
G/A |
32 |
23.4 |
4 (0-7) |
|
|
|
3 (1-5) |
|
|
|
0.11 (0-0.9) |
|
|
|
| |
|
G/G |
105 |
76.6 |
4 (0-8) |
|
|
|
3 (1-4) |
|
|
|
0.77 (0.1-1.56) |
|
|
|
Shaded cells with p values in italics, bolded and underlined indicate that a significant association (p≤0.05) was detected. Addit. – additive model; Dom. – dominant model;
Rec. – recessive model; IRQ – interquartile range. |
