Chinese (n=114) Caucasian (n=36) Estimated difference (95%CI) P-value
TOF 0.7        
Geometric mean (95% CI) 1.6 (1.5 to 1.8) 1.1 (1.0 to 1.2)   p<0.0001
Median 1.6 1.1 0.5 (0.2, 0.7)  
Range 0.6 to 9.3 0.6 to 2.8    
Upper limit of TI 4.3 2.2    
TOF 0.8        
Geometric mean (95% CI) 1.9 (1.7 to 2.1) 1.2 (1.1 to 1.3)   p<0.0001
Median 1.8 1.2 0.7 (0.4, 1.0)  
Range 0.6 to 10.1 0.6 to 3.0    
Upper limit of TI 5.0 2.4    
TOF 0.9        
Geometric mean (95% CI) 2.3 (2.1 to 2.6) 1.4 (1.3 to 1.6)   p<0.0001
Median 2.3 1.4 (0.5, 1.2)  
Range 0.6 to 14.6 0.6 to 3.3    
Upper limit of TI 6.4 3.2    
TI, tolerance interval; TOF, train-of-four.
Estimated difference and 95% CI were obtained according to Hodges-Lehmann and Moses.
p-values obtained from testing whether the ratio of the two geometric means is equal to 1 (ANOVA on log- transformed recovery times)
Table 3: Comparison of time (minutes) from administration of sugammadex to recovery of the TOF ratio to 0.7, 0.8 and 0.9 in Chinese and Caucasian patients (full analysis set).