| Summary of the metabolomics analysis for the sepsis condition |
| Approach (Un targeted/Targeted) |
Analytical techniques |
Animal/Human sampling |
Biofluid |
MVA |
Key metabolites identified |
Reference |
| Untargeted |
NMR |
Animal (Sprague-Dawleyrats) |
Serum |
Orthogonal partial least squares |
lactate, alanine, acetate, acetoacetate, hydroxybutyrate, and formate |
Lin et al. [23] |
| Targeted |
UPLC-Q-TOF-MS |
Animal (Sprague-Dawleyrats) |
Plasma |
Orthogonal partial least squares |
hypoxanthine, indoxylsufate, glucuronic acid, gluconic acid, proline, uracil, nitrotyrosine, uric acid, and trihydroxycholanoic acid |
Liu et al. [24] |
| Untargeted |
NMR |
Animal (Sprague-Dawleyrats) |
Broncho-alveolar lavage fluid (BALF), lung tissue and serum |
Partial least squares -
discriminant analysis |
alanine, creatine, phosphoethanolamine, and myoinositol increased in lung tissue; creatine increased and myoinositol decreased in balf; alanine, creatine, phosphoethanolamine, and acetoacetate increased in serum. |
Izquierdo-Garcia et al. [25] |
Untargeted
Targeted |
NMR
GC/MS |
Human (Newborns) |
Urine |
Orthogonal partial least squares- discriminant analysis |
NMR: acetate
acetone, citrate
creatinine glycine
lactate, lysine
glucose
GC/MS: lactate, glucose,, maltose,
ribitol, ribonic acid, pseudo-uridine,
2,3,4-trihydroxybutyric acid, 2-ketogluconic acid
3,4-dihydroxybutanoic acid, 3,4,5-trihydroxypentanoic acid |
Fanos et al. [22] |
| Untargeted |
NMR |
Human
(Adults) |
Serum |
Orthogonal partial least squares |
glucose, 3-hydroxybutyrate, o-acetylcarnitine, succinate, creatine, and creatine phosphatelactate, 2-hydroxyisovalerate, isobutyrate, creatinine, trimethylamine n-oxide, and ureabranched-chain amino acids |
Mickiewicz et al.[28] |
|
