Dependent Variable (I) group (J) group Mean Difference (I-J) Std. Error P value
focal thickening alveolar membranes control day 1 -1,000 ,297 ,025
    day 2 -1,400 ,279 ,000
    day 3 -2,000 ,243 ,000
    day 4 -1,455 ,234 ,000
    day 6 -2,636 ,234 ,000
  day 1 control 1,000 ,297 ,025
    day 2 -,400 ,309 1,000
    day 3 -1,000 ,277 ,012
    day 4 -,455 ,269 1,000
    day 6 -1,636 ,269 ,000
  day 2 control 1,400 ,279 ,000
    day 1 ,400 ,309 1,000
    day 3 -,600 ,257 ,368
    day 4 -,055 ,248 1,000
    day 6 -1,236 ,248 ,000
  day 3 control 2,000 ,243 ,000
    day 1 1,000 ,277 ,012
    day 2 ,600 ,257 ,368
    day 4 ,545 ,207 ,178
    day 6 -,636 ,207 ,057
  day 4 control 1,455 ,234 ,000
    day 1 ,455 ,269 1,000
    day 2 ,055 ,248 1,000
    day 3 -,545 ,207 ,178
    day 6 -1,182 ,196 ,000
  day 6 control 2,636 ,234 ,000
    day 1 1,636 ,269 ,000
    day 2 1,236 ,248 ,000
    day 3 ,636 ,207 ,057
    day 4 1,182 ,196 ,000
capillary congestion control day 1 -,917 ,374 ,279
    day 2 -,867 ,351 ,267
    day 3 -1,778 ,305 ,000
    day 4 -1,121 ,294 ,007
    day 6 -1,576 ,294 ,000
  day 1 control ,917 ,374 ,279
    day 2 ,050 ,388 1,000
    day 3 -,861 ,348 ,265
    day 4 -,205 ,338 1,000
    day 6 -,659 ,338 ,874
  day 2 control ,867 ,351 ,267
    day 1 -,050 ,388 1,000
    day 3 -,911 ,323 ,111
    day 4 -,255 ,312 1,000
    day 6 -,709 ,312 ,429
  day 3 control 1,778 ,305 ,000
    day 1 ,861 ,348 ,265
    day 2 ,911 ,323 ,111
    day 4 ,657 ,260 ,236
    day 6 ,202 ,260 1,000
  day 4 control 1,121 ,294 ,007
    day 1 ,205 ,338 1,000
    day 2 ,255 ,312 1,000
    day 3 -,657 ,260 ,236
    day 6 -,455 ,247 1,000
  day 6 control 1,576 ,294 ,000
    day 1 ,659 ,338 ,874
    day 2 ,709 ,312 ,429
    day 3 -,202 ,260 1,000
    day 4 ,455 ,247 1,000
pulmonary oedema control day 1 -,250 ,400 1,000
    day 2 -,800 ,375 ,587
    day 3 -1,111 ,326 ,023
    day 4 -,455 ,314 1,000
    day 6 -1,273 ,314 ,003
  day 1 control ,250 ,400 1,000
    day 2 -,550 ,416 1,000
    day 3 -,861 ,372 ,389
    day 4 -,205 ,362 1,000
    day 6 -1,023 ,362 ,109
  day 2 control ,800 ,375 ,587
    day 1 ,550 ,416 1,000
    day 3 -,311 ,346 1,000
    day 4 ,345 ,334 1,000
    day 6 -,473 ,334 1,000
  day 3 control 1,111 ,326 ,023
    day 1 ,861 ,372 ,389
    day 2 ,311 ,346 1,000
    day 4 ,657 ,278 ,350
    day 6 -,162 ,278 1,000
  day 4 control ,455 ,314 1,000
    day 1 ,205 ,362 1,000
    day 2 -,345 ,334 1,000
    day 3 -,657 ,278 ,350
    day 6 -,818 ,264 ,053
  day 6 control 1,273 ,314 ,003
    day 1 1,023 ,362 ,109
    day 2 ,473 ,334 1,000
    day 3 ,162 ,278 1,000
    day 4 ,818 ,264 ,053
intra-alveolar haemorrhage control day 1 -,500 ,303 1,000
    day 2 -,600 ,284 ,612
    day 3 -1,556 ,247 ,000
    day 4 -1,273 ,238 ,000
    day 6 -1,727 ,238 ,000
   day 1 control ,500 ,303 1,000
    day 2 -,100 ,314 1,000
    day 3 -1,056 ,282 ,008
    day 4 -,773 ,274 ,110
    day 6 -1,227 ,274 ,001
  day 2 control ,600 ,284 ,612
    day 1 ,100 ,314 1,000
    day 3 -,956 ,261 ,011
    day 4 -,673 ,253 ,167
    day 6 -1,127 ,253 ,001
  day 3 control 1,556 ,247 ,000
    day 1 1,056 ,282 ,008
    day 2 ,956 ,261 ,011
    day 4 ,283 ,211 1,000
    day 6 -,172 ,211 1,000
  day 4 control 1,273 ,238 ,000
    day 1 ,773 ,274 ,110
    day 2 ,673 ,253 ,167
    day 3 -,283 ,211 1,000
    day 6 -,455 ,200 ,426
  day 6 control 1,727 ,238 ,000
    day 1 1,227 ,274 ,001
    day 2 1,127 ,253 ,001
    day 3 ,172 ,211 1,000
    day 4 ,455 ,200 ,426
interstitial neutrophil infiltration control day 1 -1,000(*) ,311 ,039
    day 2 -1,000 ,292 ,022
    day 3 -1,556 ,254 ,000
    day 4 -1,364 ,245 ,000
    day 6 -2,364 ,245 ,000
  day 1 control 1,000 ,311 ,039
    day 2 ,000 ,324 1,000
    day 3 -,556 ,290 ,938
    day 4 -,364 ,282 1,000
    day 6 -1,364 ,282 ,000
  day 2 control 1,000 ,292 ,022
    day 1 ,000 ,324 1,000
    day 3 -,556 ,269 ,683
    day 4 -,364 ,260 1,000
    day 6 -1,364 ,260 ,000
  day 3 control 1,556 ,254 ,000
    day 1 ,556 ,290 ,938
    day 2 ,556 ,269 ,683
    day 4 ,192 ,217 1,000
    day 6 -,808 ,217 ,009
  day 4 control 1,364 ,245 ,000
    day 1 ,364 ,282 1,000
    day 2 ,364 ,260 1,000
    day 3 -,192 ,217 1,000
    day 6 -1,000 ,206 ,000
  day 6 control 2,364 ,245 ,000
    day 1 1,364 ,282 ,000
    day 2 1,364 ,260 ,000
    day 3 ,808 ,217 ,009
    day 4 1,000 ,206 ,000
intra-alveolar neutrophil infiltration control day 1 ,000 ,345 1,000
    day 2 -,200 ,324 1,000
    day 3 -,778 ,282 ,131
    day 4 -,273 ,271 1,000
    day 6 -1,091 ,271 ,004
  day 1 control ,000 ,345 1,000
    day 2 -,200 ,359 1,000
    day 3 -,778 ,321 ,303
    day 4 -,273 ,312 1,000
    day 6 -1,091 ,312 ,018
  day 2 control ,200 ,324 1,000
    day 1 ,200 ,359 1,000
    day 3 -,578 ,298 ,899
    day 4 -,073 ,289 1,000
    day 6 -,891 ,289 ,055
  day 3 control ,778 ,282 ,131
    day 1 ,778 ,321 ,303
    day 2 ,578 ,298 ,899
    day 4 ,505 ,240 ,630
    day 6 -,313 ,240 1,000
  day 4 control ,273 ,271 1,000
    day 1 ,273 ,312 1,000
    day 2 ,073 ,289 1,000
    day 3 -,505 ,240 ,630
    day 6 -,818 ,228 ,014
  day 6 control 1,091 ,271 ,004
    day 1 1,091 ,312 ,018
    day 2 ,891 ,289 ,055
    day 3 ,313 ,240 1,000
    day 4 ,818 ,228 ,014
% expression Ki-67 control day 1 -2,000 2,292 1,000
    day 2 -3,500 2,150 1,000
    day 3 -,944 1,871 1,000
    day 4 -8,409 1,802 ,001
    day 6 -10,136 1,802 ,000
  day 1 control 2,000 2,292 1,000
    day 2 -1,500 2,382 1,000
    day 3 1,056 2,133 1,000
    day 4 -6,409 2,073 ,054
    day 6 -8,136 2,073 ,005
  day 2 control 3,500 2,150 1,000
    day 1 1,500 2,382 1,000
    day 3 2,556 1,980 1,000
    day 4 -4,909 1,915 ,213
    day 6 -6,636 1,915 ,019
  day 3 control ,944 1,871 1,000
    day 1 -1,056 2,133 1,000
    day 2 -2,556 1,980 1,000
    day 4 -7,465 1,596 ,000
    day 6 -9,192 1,596 ,000
  day 4 control 8,409 1,802 ,001
    day 1 6,409 2,073 ,054
    day 2 4,909 1,915 ,213
    day 3 7,465 1,596 ,000
    day 6 -1,727 1,514 1,000
  day 6 control 10,136 1,802 ,000
    day 1 8,136 2,073 ,005
    day 2 6,636 1,915 ,019
    day 3 9,192 1,596 ,000
    day 4 1,727 1,514 1,000
% expression TUNEL test control day 1 -1,750 1,480 1,000
    day 2 -1,200 1,389 1,000
    day 3 -9,222 1,209 ,000
    day 4 -4,364 1,164 ,008
    day 6 -9,455 1,164 ,000
  day 1 control 1,750 1,480 1,000
    day 2 ,550 1,538 1,000
    day 3 -7,472 1,378 ,000
    day 4 -2,614 1,339 ,870
    day 6 -7,705 1,339 ,000
  day 2 control 1,200 1,389 1,000
    day 1 -,550 1,538 1,000
    day 3 -8,022 1,279 ,000
    day 4 -3,164 1,237 ,217
    day 6 -8,255 1,237 ,000
  day 3 control 9,222 1,209 ,000
    day 1 7,472 1,378 ,000
    day 2 8,022 1,279 ,000
    day 4 4,859 1,031 ,000
    day 6 -,232 1,031 1,000
  day 4 control 4,364 1,164 ,008
    day 1 2,614 1,339 ,870
    day 2 3,164 1,237 ,217
    day 3 -4,859 1,031 ,000
    day 6 -5,091 ,978 ,000
  day 6 control 9,455 1,164 ,000
    day 1 7,705 1,339 ,000
    day 2 8,255 1,237 ,000
    day 3 ,232 1,031 1,000
    day 4 5,091 ,978 ,000
% expression p21 control day 1 -,083 1,319 1,000
    day 2 -4,133 1,237 ,027
    day 3 -8,222 1,077 ,000
    day 4 -10,515 1,037 ,000
    day 6 -4,515 1,037 ,001
  day 1 control ,083 1,319 1,000
    day 2 -4,050 1,371 ,078
    day 3 -8,139 1,228 ,000
    day 4 -10,432 1,193 ,000
    day 6 -4,432 1,193 ,009
  day 2 control 4,133 1,237 ,027
    day 1 4,050 1,371 ,078
    day 3 -4,089 1,140 ,014
    day 4 -6,382 1,102 ,000
    day 6 -,382 1,102 1,000
  day 3 control 8,222 1,077 ,000
    day 1 8,139 1,228 ,000
    day 2 4,089 1,140 ,014
    day 4 -2,293 ,919 ,252
    day 6 3,707 ,919 ,004
  day 4 control 10,515 1,037 ,000
    day 1 10,432 1,193 ,000
    day 2 6,382 1,102 ,000
    day 3 2,293 ,919 ,252
    day 6 6,000 ,871 ,000
  day 6 control 4,515 1,037 ,001
    day 1 4,432 1,193 ,009
    day 2 ,382 1,102 1,000
    day 3 -3,707 ,919 ,004
    day 4 -6,000 ,871 ,000
% expression p16 control day 1 -,500 1,691 1,000
    day 2 -5,600 1,586 ,016
    day 3 -11,778 1,381 ,000
    day 4 -12,273 1,329 ,000
    day 6 -8,364 1,329 ,000
  day 1 control ,500 1,691 1,000
    day 2 -5,100 1,757 ,090
    day 3 -11,278 1,574 ,000
    day 4 -11,773 1,529 ,000
    day 6 -7,864 1,529 ,000
  day 2 control 5,600 1,586 ,016
    day 1 5,100 1,757 ,090
    day 3 -6,178 1,461 ,002
    day 4 -6,673 1,413 ,000
    day 6 -2,764 1,413 ,862
  day 3 control 11,778 1,381 ,000
    day 1 11,278 1,574 ,000
    day 2 6,178 1,461 ,002
    day 4 -,495 1,177 1,000
    day 6 3,414 1,177 ,091
  day 4 control 12,273 1,329 ,000
    day 1 11,773 1,529 ,000
    day 2 6,673 1,413 ,000
    day 3 ,495 1,177 1,000
    day 6 3,909 1,117 ,017
  day 6 control 8,364 1,329 ,000
    day 1 7,864 1,529 ,000
    day 2 2,764 1,413 ,862
    day 3 -3,414 1,177 ,091
    day 4 -3,909 1,117 ,017
 % expression p27 control day 1 -,083 1,998 1,000
    day 2 -4,433 1,874 ,344
    day 3 -7,500 1,631 ,001
    day 4 -12,652 1,571 ,000
    day 6 -10,288 1,571 ,000
  day 1 control ,083 1,998 1,000
    day 2 -4,350 2,076 ,638
    day 3 -7,417 1,860 ,004
    day 4 -12,568 1,807 ,000
    day 6 -10,205 1,807 ,000
  day 2 control 4,433 1,874 ,344
    day 1 4,350 2,076 ,638
    day 3 -3,067 1,726 1,000
    day 4 -8,218 1,669 ,000
    day 6 -5,855 1,669 ,017
  day 3 control 7,500 1,631 ,001
    day 1 7,417 1,860 ,004
    day 2 3,067 1,726 1,000
    day 4 -5,152 1,391 ,010
    day 6 -2,788 1,391 ,778
  day 4 control 12,652 1,571 ,000
    day 1 12,568 1,807 ,000
    day 2 8,218 1,669 ,000
    day 3 5,152 1,391 ,010
    day 6 2,364 1,320 1,000
  day 6 control 10,288 1,571 ,000
    day 1 10,205 1,807 ,000
    day 2 5,855 1,669 ,017
    day 3 2,788 1,391 ,778
    day 4 -2,364 1,320 1,000
 % expression cyclin B  control day 1 -,083 1,980 1,000
    day 2 -5,833 1,858 ,048
    day 3 -13,611 1,617 ,000
    day 4 -15,197 1,557 ,000
    day 6 -12,288 1,557 ,000
              day 1 control ,083 1,980 1,000
    day 2 -5,750 2,058 ,119
    day 3 -13,528 1,843 ,000
    day 4 -15,114 1,791 ,000
    day 6 -12,205 1,791 ,000
  day 2 control 5,833 1,858 ,048
    day 1 5,750 2,058 ,119
    day 3 -7,778 1,711 ,001
    day 4 -9,364 1,655 ,000
    day 6 -6,455 1,655 ,005
  day 3 control 13,611 1,617 ,000
    day 1 13,528 1,843 ,000
    day 2 7,778 1,711 ,001
    day 4 -1,586 1,379 1,000
    day 6 1,323 1,379 1,000
  day 4 control 15,197 1,557 ,000
    day 1 15,114 1,791 ,000
    day 2 9,364 1,655 ,000
    day 3 1,586 1,379 1,000
    day 6 2,909 1,308 ,478
  day 6 control 12,288 1,557 ,000
    day 1 12,205 1,791 ,000
    day 2 6,455 1,655 ,005
    day 3 -1,323 1,379 1,000
    day 4 -2,909 1,308 ,478
% expression cyclin D1 control day 1 -,500 2,124 1,000
    day 2 -8,000 1,992 ,004
    day 3 -14,222 1,734 ,000
    day 4 -11,455 1,670 ,000
    day 6 -9,818 1,670 ,000
   day 1 control ,500 2,124 1,000
    day 2 -7,500 2,207 ,023
    day 3 -13,722 1,977 ,000
    day 4 -10,955 1,921 ,000
    day 6 -9,318 1,921 ,000
  day 2 control 8,000 1,992 ,004
    day 1 7,500 2,207 ,023
    day 3 -6,222 1,835 ,024
    day 4 -3,455 1,774 ,879
    day 6 -1,818 1,774 1,000
  day 3 control 14,222 1,734 ,000
    day 1 13,722 1,977 ,000
    day 2 6,222 1,835 ,024
    day 4 2,768 1,479 1,000
    day 6 4,404 1,479 ,074
  day 4 control 11,455 1,670 ,000
    day 1 10,955 1,921 ,000
    day 2 3,455 1,774 ,879
    day 3 -2,768 1,479 1,000
    day 6 1,636 1,403 1,000
  day 6 control 9,818 1,670 ,000
    day 1 9,318 1,921 ,000
    day 2 1,818 1,774 1,000
    day 3 -4,404 1,479 ,074
    day 4 -1,636 1,403 1,000
% expression cyclin E control day 1 -,250 2,111 1,000
    day 2 -6,200 1,980 ,049
            day 3 -13,889 1,723 ,000
    day 4 -15,364 1,660 ,000
    day 6 -10,455 1,660 ,000
  day 1 control ,250 2,111 1,000
    day 2 -5,950 2,194 ,147
    day 3 -13,639 1,965 ,000
    day 4 -15,114 1,909 ,000
    day 6 -10,205 1,909 ,000
  day 2 control 6,200 1,980 ,049
    day 1 5,950 2,194 ,147
    day 3 -7,689 1,824 ,002
    day 4 -9,164 1,764 ,000
    day 6 -4,255 1,764 ,308
  day 3 control 13,889 1,723 ,000
    day 1 13,639 1,965 ,000
    day 2 7,689 1,824 ,002
    day 4 -1,475 1,470 1,000
    day 6 3,434 1,470 ,368
  day 4 control 15,364 1,660 ,000
    day 1 15,114 1,909 ,000
    day 2 9,164 1,764 ,000
    day 3 1,475 1,470 1,000
    day 6 4,909 1,394 ,016
  day 6 control 10,455 1,660 ,000
    day 1 10,205 1,909 ,000
    day 2 4,255 1,764 ,308
    day 3 -3,434 1,470 ,368
    day 4 -4,909 1,394 ,016
Table 3: Multiple comparisons between all pairs of variables with the Bonferroni test.