Invasive measurements Remifentanil Sufentanil Δ-values (After – Before)
Before After p-value Before After p-value Remifentanil Sufentanil p-value
Cardiac Index (L/m2/minute) 3.5 ± 0.8 3.2 ± 0.6 0.137#) 3.2 ± 0.8 3.2 ± 0.8 0.900#) -0.34 ± 0.80 0.01 ± 0.50 0.180!)
Heart rate (beats/minute) 72 ± 8 69 ± 10 0.151#) 69 ± 9 66 ± 13 0.166#) -3.1 ± 7.7 -2.9 ± 7.0 0.930!)
Mean Arterial Pressure (mmHg) 104 ± 13 91 ± 15 0.001#) 107 ± 21 94 ± 24 0.003#) -12.8 ± 11.5 -13.1 ± 12.4 0.933!)
Central venous pressure (mmHg) 6 ± 7 7 ± 7 0.366#) 7 ± 7 10 ± 6 0.022#) 1.5 ± 6.3 2.7 ± 3.7 0.572!)
Pulmonary artery Pressure (mmHg) 17 ± 4 21 ± 7 0.020#) 19 ± 9 23 ± 9 0.036#) 3.7 ± 5.3 3.9 ± 6.0 0.927!)
Central venous oxygenation (%) 74 ± 6 77 ± 9 0.221#) 76 ± 4 74 ± 8 0.436#) 2.6 ± 7.4 -1.9 ± 8.6 0.155!)
Peripheral saturation (%) 97 ± 3 98 ± 3 0.236#) 98 ± 3 97 ± 4 0.827#) 1.2 ± 3.5 -0.3 ± 4.6 0.372!)
Stroke volume Index (ml/m2/beat) 48.8 ± 13.3 45.6 ± 7.9 0.399#) 46.4 ± 13.2 49.4 ± 13.3 0.240#) -3.1 ± 13.5 3.0 ± 8.7 0.176!)
Echocardiographic measurements                  
Global longitudinal peak systolic strain (%) -16 (-18 - -13) -16 (-18 - -15) 0.068*) -14 (-17 - -13) -15 (-16 – 15) 0.492*) -1.9 (-4.0 - 0.7) -1.3 (-3.1 - 1.3) 0.697&)
S-max (average lateral and medial) 9.2 ± 2.0 9.6 ± 2.4 0.307#) 8.8 ± 1.5 8.7 ± 1.9 0.705#) 0.5 ± 1.6 -0.1 ± 0.8 0.150 !)
E/E' ratio (average medial/lateral) 9.0 (6.5 – 10.6) 8.0 (6.0 – 9.4) 0.502*) 7.3 (6.3 – 8.2) 8.3 (6.4 – 10.5) 0.557*) 0.8 (-2.5 - 1.0) -1.0 (-1.7 - 2.7) 0.447&)
E’/A’ ratio (average medial/lateral) 0.8 (0.7 – 0.9) 0.8 (0.7 – 1.0) 0.685*) 0.9  (0.8 – 1.0) 0.8 (0.6 – 1.0) 0.922*) 0.1 (-0.1 - 0.1) 0.0 (-0.2 - 0.1) 0.687&)
E’ – TD early diastolic velocity (cm/s) 9.2 ± 1.6 9.9 ± 1.6 0.164#) 10.1 ± 1.7 10.0 ± 2.2 0.834#) -0.7 ± 1.5 0.1 ± 1.5 0.244 !)
A’ – TD atrial diastolic velocity (cm/s) 11.3 ± 2.3 12.3 ± 3.4 0.226#) 11.3 ± 1.8 11.6 ± 2.8 0.824#) -1.0 ± 2.8 -0.2 ± 2.2 0.432 !)
Table 2: Haemodynamic and echocardiographic data before and after opioid administration. Statistics: #) Paired samples t-test; *) Wilcoxon test; !) Independent samples t-test; &) Mann-Whitney test; TD: Tissue Doppler. Δ-values are differences of values obtained after drug administration minus values before administration.