Conducting:   Report:  
Question Assessment Question Assessment
Are definitions of reported adverse effects given? They were not described. Were adverse effects reported adequately? It is not clear. They just described that there were not AE.
Were the methods used for monitoring adverse effects reported? Use of prospective or routine monitoring; spontaneous reporting; patient checklist, questionnaire or diary; systematic survey of They were not described. •     Were any patients excluded from the adverse effects analysis? There is not a description. 75 patients were excluded for UTI before cystoscopy and 30 patients for absence of urine culture after procedure.
Were the methods to detect AE rigorous? There is not a description. Does the report provide numerical data by intervention group? No patient had any AE.
    •     Which categories of adverse effects were reported by the investigators? There is not a description.
    •     Did the researchers report all important or serious adverse effects? How were these AE defined? There is not a description.
    Were reported the adverse effects considered for monitoring? There is not a description. 
Table 3: Risk of Bias for Adverse effects Jiménez-Cruz, [10].