Figure 1: Action of dexmedetomidine on the neurotransmitter signaling in the synapse. Dex or Clonidine can work as an agonist for the alpha-2 adrenoceptor, an opioid receptor. This interaction had a negative effect on the release of the neurotransmitter which eventually results in the attenuation of neurotransduction, such as the pain relief. Modified from Dexmedetomidine. com and Gertler et al., [24].