Historic Controls n=68 Study Group n=104 p-value Type of surgical resection, n (%) Minor Major Extended 37 (54) 9 (13) 21 (31) 58 (56) 13 (13) 33 (32) 0.66 Surgical time, min (range) 192 (150-240) 195 (155-240) 0.66 Laparoscopic approach, n (%) 10 (15) 31 (30) 0.02 Peridural, n (%) Blood loss, ml (range) Blood component transfusion Intraoperative Patients receiving RBC, n (%) RBC# , U Patients receiving FFP, n (%) FFP#, mL Patients receiving platelets, n (%) Postoperative Patients receiving RBC, n (%) RBC#, U Patients receiving FFP, n (%) FFP#, mL Patients receiving platelets, n (%) 33 (48) 200 (110-500) 12 (18) 2 (2-3.7) 34 (50) 1000 (1000-1000) 0 10 (15) 2 (2-3) 3 (4) 500 (500- 1000) 1(1.5) 56 (54) 200 (100-350) 6 (6) 2 (1-2) 0 0 0 8 (8) 2 (2-4) 2 (2) 1000 (1000-1000) 0 0.39 0.16 0.02 0.01 <0.01 <0.01 1 0.20 0.15 0.38 0.34 0.39 Definition of Abbreviations: p value= statistical significance comparing both groups; # data only from transfused patients. RBC: red blood cells. FFP: Fresh Frozen Plasma. Data expressed as median (25-75%)

Table 2: Comparison of perioperative data between historic controls (2009) and study group (January 2012-June 2013).