| Group |
|
15D |
30D |
15L |
30L |
| Number of animals |
|
5 |
9 |
11 |
9 |
| RR (breaths/minute) |
T0
T1 |
10.2 ± 3.2†‡
11.3 ± 2.3†‡ |
5.9 ± 1.3
5.3 ± 0.7 |
9.4 ± 2.6†‡
10.1 ± 2.5†‡ |
5.2 ± 0.8
5.1 ± 0.5 |
| VT
(ml/kg) |
T0
T1 |
9.2 ± 2.3†‡¤
8.5 ± 2†‡¤ |
16.6 ± 2.8‡¤#
16.6 ± 2‡¤# |
8 ± 1.8†‡#
8 ± 1.8†‡# |
14.2 ± 2.3†‡#
15.4 ± 2.8†¤# |
| Minute Volume (RR x VT) |
T0
T1 |
94.4 ± 36.4‡¤
93.7 ± 19.3‡¤ |
96.1 ± 20.6‡¤
86 ± 8.5‡¤ |
73.4 ± 19.9
80.1 ± 22.6 |
72.2 ± 13
77.3 ± 14.9 |
| ETCO2 (mmHg) |
T0
T1 |
43.2 ± 11.4*
40.5 ± 4.8 |
35.6 ± 4.5*
29.5 ± 3.4 |
44.4 ± 9.6*
41.8 ± 6.6 |
33 ± 3.2*
29.1 ± 3.3 |
| ETISO
(%) |
T0
T1 |
1.3 ± 0.3
1.2 ± 0.3 |
1.1 ± 0.2
1.1 ± 0.1 |
1.1 ± 0.1
1.1 ± 0.1 |
1 ± 0.2
1.1 ± 0.1 |
| HR (beats/minute) |
T0
T1 |
40.6 ± 9.6*
41.8 ± 7.1 |
39.2 ± 4.8*
40.2 ± 3.8 |
34.4 ± 5.6*
40.2 ± 5.9 |
36.2 ± 7.5*
39.7 ± 8.6 |
| MAP
(mmHg) |
T0
T1 |
69.2 ± 21.2*
75.5 ± 16.1 |
73.4 ± 17.5*
84.7 ± 6.8 |
77.8 ± 7.9*
84.1 ± 10.3 |
80 ± 15.8*
86 ± 22.8 |
| PaO2 (kPa) |
T0
T1 |
np
22.8 ± 8.7 |
np
28.7 ± 17.4 |
np
31 ± 9.4 |
np
32.2 ± 6.5 |
| PaCO2 (kPa) |
T0
T1 |
np
7.1 ± 0.8 |
np
5.2 ± 0.4 |
np
6.8 ± 1 |
np
5.2 ± 1 |
| SpO2 (%) |
T0
T1 |
np
98.9 ± 1.2 |
np
98.5 ± 2.7 |
np
99.7 ± 0.3 |
np
99.8 ± 0.1 |
| PAO2 (kPa) |
T0
T1 |
np
61 ± 7.7 |
np
66.6 ± 8 |
np
62.1 ± 6 |
np
62.7 ± 5.6 |
| BE |
T0
T1 |
np
3.75 (0.5-6.8)§ |
np
3.25 ± 0.82 |
np
5.2 ± 1.7 |
np
4.13 ± 1.1 |
| HCO3- |
T0
T1 |
np
30.3 ± 3.3 |
np
27.3 ± 1.2 |
np
30.7 ± 2.8 |
np
24.6 ± 5.7 |
| pH |
T0
T1 |
np
7.4 ± 0.0 |
np
7.5 ± 0.0 |
np
7.4 ± 0.0 |
np
7.4 ± 0.1 |
Data are shown as mean ± standard deviation. §Values reported as median and range because they were not normally distributed. Np: not performed. †significantly different
(p<0.05) from 30D; ‡significantly different (p<0.05) from 30L; ¤significantly different (p<0.05) from 15L; #significantly different (p<0.05) from 15D; *significantly different
(p<0.05) from T1. 15D: low pressure-low volume MV in dorsal recumbency; 30D: high pressure-high volume MV in dorsal recumbency; 15L: low pressure-low volume MV in
lateral recumbency; 30L: high pressure-high volume MV in lateral recumbency; T0: at the beginning of mechanical ventilation; T1: after 60 minutes of mechanical ventilation;
RR: respiratory rate; VT: tidal volume; PIP: peak inspiratory pressure; ETCO2: end-tidal carbon dioxide; ETISO: end-tidal isoflurane; HR: heart rate; MAP: mean arterial
blood pressure; PaO2: arterial partial pressure of oxygen; PaCO2: arterial partial pressure of carbon dioxide; SpO2: saturation of hemoglobin with oxygen; PAO2: alveolar partial pressure of oxygen; BE: base excess; HCO2-: bicarbonate |
