Figure 1: Experimental design. Diabetic mice were induced by four times injections of alloxan. One week after alloxan injections, mice with blood glucose over 540 mg/dL were considered diabetes. Mice were randomly divided by three groups, which are control group, diabetes group and vanadium group (Diabetes+Vanadium). Vanadium group were treated with vanadium complex daily for three weeks. And then open-field test and Morris Water Maze test were performed. After behavioral experiment, animals were sacrificed by decapitation.