Figure 2: Antihyperglycemic medication changes during the course of the study by treatment group Among Subjects with a Baseline A1C of ≥ 7.5. Relative to participants randomized to bromocriptine-QR (solid bar), more participants randomized to placebo (striped bar) increased the dose of a concomitant oral antihyperglycemic agent (OAA); 41% versus 27%, P = 0.04 or added a new OAA or insulin; 18% versus 8%, p = 0.03. Even though placebo-treated participants intensified their antihyperglycemic regimen more frequently, participants on bromocriptine-QR achieved better glycemic control over the 52 week treatment period.