Figure 5: Effects of S43126 on Ca2+ oscillations. S43126 evoked a dosedependent increase in cytosolic Ca2+ under (3A) conditions of basal glucose (2.8 mM). (B) S43126 [10-5M] caused an increase in [Ca2+]i that was greater than the influx caused by 2.8 mM glucose but less than the influx caused by 16.7 mM glucose at all time points studied. Data are presented as mean percent change +/- standard error from eight separate experiments (***p< 0.001 2.8 mM Glucose (control) vs S43126 [10μM] & 16.7mM Glucose at the same time, one-way ANOVA).