Figure 6: Effects of S43126 on 45Ca2+ uptake. (A) S43126 [10-5M] induced a time–dependent increase in 45Ca2+ influx up to 5mins, followed by a decline> at 10 min and then a plateau between 30-60 mins. Data are presented as mean percent change +/- standard error from four separate experiments run in duplicate. (***p< 0.001 Control vs S43126 [10 μM] at the same time, two-way ANOVA). (B) The 45Ca2+ influx mediated by S43126 [10-5M] was attenuated in the presence of efaroxan [100 μM] and nifedipine [10 μM]. The data are presented as mean percent change +/- S.E. from four separate experiments run in duplicate. (a= ***p< 0.001 Control vs S, E, E+S, N, N+S, b= ***p< 0.001 E vs S, E+S and c= ***p< 0.001 N vs S, N+S, one-way ANOVA).