Baseline characteristics

No Nephropathy

Nephropathy

Undetermined

ACEIs/ARBs

(n=1,070)

No ACEIs/ARBs

(n=1,557)

ACEIs/ARBs

(n=1,106)

No ACEIs/ARBs

(n=740)

ACEIs/ARBs

(n=1,365)

No ACEIs/ARBs

(n=2,108)

Male

380 (35.5)

464 (29.8)

460 (41.6)

244 (33.0)

398 (29.2)

601 (28.5)

Age, (year)

61.8±10.2

59.2±11.5

62.4±10.6

62.1±12.0

62.4±10.4

59.6±11.8

Duration of DM, (year)

10.1±7.2

9.1±7.4

12.1±8.1

11.9±8.3

10.7±7.2

9.1±7.1

Onset of DM, (year)

51.7±10.9

50.1±11.1

50.3±11.3

50.2±12.1

51.6±10.5

50.4±11.3

Body mass index, (kg/m2)

26.0±3.9

25.2±4.1

26.0±4.4

25.8±4.7

26.1±4.5

25.4±4.3

Systolic blood pressure, (mmHg)

145.1±21.3

137.0±19.9

150.3±24.7

147.1±24.8

146.9±21.6

138.1±19.9

Diastolic blood pressure, (mmHg)

79.0±11.2

77.0±10.7

79.4±12.6

77.4±11.6

80.6±10.8

79.0±10.3

HbA1C, (%)

7.9±1.7

7.9±1.7

8.5±2.1

8.4±2.0

8.2±1.8

8.2±1.9

Cholesterol, (mmol/L)

4.9±0.9

5.0±1.0

5.1±1.2

5.3±1.4

5.2±1.1

5.2±1.1

Triglyceride, (mmol/L)

1.6±0.9

1.5±0.9

1.9±1.6

2.0±1.6

1.8±1.0

1.8±1.3

High density lipoprotein, (mmol/L)

1.4±0.4

1.3±0.4

1.3±0.4

1.3±0.3

1.4±0.4

1.3±0.4

Low density lipoprotein, (mmol/L)

2.8±0.8

2.9±0.8

3.0±1.0

3.0±1.1

3.1±0.9

3.0±0.9

Creatinine, (mmol/L)

89.5±44.7

86.9±100.5

121.2±68.2

152.8±121.9

103.1±44.8

96.4±41.0

Ischemic heart disease

88 (8.3)

89 (5.7)

119 (10.8)

80 (10.9)

147 (10.9)

148 (7.1)

History of dyslipidemia

874 (81.7)

1,130 (72.6)

876 (79.2)

563 (76.1)

1,023 (74.9)

1,386 (65.8)

History of hypertension

991 (92.6)

609 (39.1)

984 (89.0)

530 (71.6)

1,275 (93.4)

939 (44.5)

Smoking

200 (18.7)

276 (17.7)

303 (27.4)

165 (22.3)

234 (17.1)

376 (17.8)

Alcohol drinking

195 (18.2)

245 (15.7)

260 (23.5)

143 (19.3)

242 (17.7)

412 (19.5)

Use of insulin

221 (20.7)

300 (19.3)

393 (35.5)

310 (41.9)

325 (23.8)

461 (21.9)

Use of antihyperglycemic drugs

999 (93.4)

1,246 (91.4)

941 (85.1)

522 (70.5)

1,246 (91.3)

1,891 (89.7)

Use of antihypertensive drugs

573 (53.6)

484 (31.1)

656 (59.3)

478 (64.6)

818 (59.9)

794 (37.7)

Use of antidyslipidemic drugs

712 (66.5)

895 (57.5)

708 (64.0)

442 (59.7)

746 (54.7)

917 (43.5)

Propensity score

0.50±0.12

0.42±0.12

0.51±0.14

0.48±0.14

0.47±0.13

0.40±0.13

Table 1: Baseline characteristics of patients prescribed (n=3,541) or not prescribed (n=4,405) ACEIs/ARBs, classified by nephropathy status at registration