Concentration
(µg equivalents/g tissue)

Tissue-to-Blood Ratio

Tissue

0.25 hr a

1 hr

4 hr

24 hr

0.5 hr

4 hr

8 hr

24 hr

Blood

2.92

3.56

1.02

0.15

1.00

1.00

1.00

1.00

Brain

0.24

0.53

0.14

BLQ b

0.08

0.15

0.14

NC

Harderian Gland

1.25

3.73

1.24

0.31

0.43

1.05

1.21

2.10

Heart

2.64

2.58

0.72

0.09

0.90

0.76

0.70

0.64

Kidney

11.0

14.1

3.96

0.41

3.75

3.97

3.87

2.79

Liver

32.8

16.3

9.06

1.72

11.2

4.57

8.87

11.7

Muscle

0.75

1.65

0.47

BLQ

0.26

0.46

0.46

NC

an = 1 animal per time point
bAbbreviations: BLQ: Below Limit of Quantification; NC = Not Calculated
Table 5: Tissue Concentrations and Tissue-to-Blood Ratios of Radioactivity in Male Rats After A Single Oral Administration of 25 mg/kg [14C]-Remogliflozin etabonate.