Protein name Gene name Change in expression Microarray experiment
6-Phosphogluconolactonase PGLS
Acetyl coenzyme A acyltransferase ACAT1 M
Adenylate kinase 2 isoform a AK2
Adenylate dehydrogenase 1A3 ALDH1A3
Aldehyde dehydrogenase X ALDH1B1
Aldose reductase  AKR1B1
Carbonyl reductasea CBR1  
Cathepsin B CTSD
Coproporphyrinogen oxidase CPOX  
Glutathione synthetase GSS  
Glutathione-S-transferasea chain A GSTA2
Phosphoenolpyruvate carboxykinase pck1  
Protein-L-isoaspartate O-methyltransferase PCMT1  
Pyridoxine 5’-phosphate oxidase PNPO  
Pyrophosphatase (inorganic) PPA1  
Host cell proteins were designated as being down regulated in expression (↓), upregulated (↑), or modulated (M). Modulated proteins had expression altered across several isoforms on the same gel using the Amersham difference gel electrophoresis, and this probably indicated a posttranslational modification event [354]. aThe host cell proteins, which also changed expression in the brains of patients with mild cognitive impairement, early AD, or AD [369]
Table 20: Selected modifications in the proteomes of human foreskin fibroblasts infected with T. gondii: proteins implicated in metabolism (Nelson et al. [368]; with own modification).