Figure 1: Schematic diagram of the promoter of human toll-like receptor (TLR) 4 gene is represented with (A) Genomic sequence of the TLR4 promoter region ranging from -1038 bp to - 611 bp (GenBank accession number AF172169) with CpG sites studied in bold and underlined. (B) Representative diagram of the human TLR4 promoter. Transcription factor (sp-1) binding site is indicated as a circle. Cut site for restriction enzyme AciI are represented as rectangles.