Figure 1: AGEs accumulation on bone collagen is a central mechanism for Diabetic osteopathy. Uncompensated Diabetes mellitus elevates circulating reactive oxygen species, glucose and/or carbonyl stress, which can induce excess AGEs formation on bone extracellular matrix. Accumulation of collagen-AGEs reduces bone quality, strength and post-yield properties. Additionally, collagen-AGEs interact with the receptor for AGEs expressed by bone cells, inhibiting their functionality and decreasing bone turnover. This induces an even greater accumulation of AGEs in bone with development of diabetic osteopathy, thus increasing fracture risk. AGEs: Advanced Glycation End Products. RAGE: Receptor for AGEs.