Basal 3 Months FU P value
Weight(kg) 80.9 ± 16.2 79 ± 15.4 P<0.05
BMI 30.8 ± 5.2 29.7 ± 5.3 P<0.05
Conventionalechocardiography
LVEF(%) 65.8 ±5.6 68.4 ± 7.4 ns
EDV(mL) 73.8 ± 15 67.5 ± 12.6 ns
ESV(mL) 25.2 ± 6.8 21.4 ± 6.6 ns
DecT (s) 0.22 ± 0.04 0.19 ± 0.02 ns
E/A 1.23 ± 0.38 1.11 ± 0.36 ns
TDI
Em(cm/s) 10.6 ± 2.8 9.7 ± 1.9 ns
E/Em 8.87 ± 2.39 8.56 ± 2.49 ns
Sm(cm/s) 6.97 ± 1.19 7.58 ± 1 P<0.01
Speckle Tracking Echocardiography
GLS(%) 15.4% ± 3.1% 20.2% ± 4.2% P<0.001
GLSR(s-1) 1.06 ± 0.26 1.3 ± 0.33 P<0.05
Endothelial function
EFR 1.88 ± 0.47 2.10 ± 0.43 P<0.05
Abbreviations: BMI: Body Mass Index; LVEF: Left Ventricular Ejection Fraction; EDV: End Diastolic Volume; ESV End Systolic Volume; DecT: Deceleration Time; E/A: Early and Late Diastolic Peak Velocity Ratio; Em: TD Early Diastolic Peak Velocity; Em/Am: TD Early and Late Diastolic Peak Velocity Ratio; E/Em: Early Diastolic Peak Flow Velocity and TD Velocity Ratio; GLS: Global Longitudinal Strain; GLSR: Global Longitudinal Strain Rate; EFR: Endothelial Flow Reserve
Table 2: Endothelial and myocardial echocardiographic parameters at baseline and after 3-months metformin treatment.