Figure 3: Histological aspect of a neuropathic ulcer granulation tissue. H/E × 20. The absence of a mature and condensed extracellular matrix, given by thin collagen fibers and relative productive acellularity is a distinguishing aspect of the neuropathic granulation tissue. Inset: Abnormal vascular morphogenesis. Note the endothelial nuclear hypertrophy. Arrow: an incipient vessel with remarkably thickened wall. Note the almost complete luminal occlusion.