Figure 4: Histological aspect of an ischemic ulcer granulation tissue. H/E × 20. Note that the abnormal angiogenesis is the predominant aspect of these wounds. The thick arrow indicates a vessel with a dramatic wall thickening with possible fusion of the tunica media and the perivascular collagen. Other thickened vessels can be observed. Endothelial nuclear hypertrophy and media nuclear polymorphism predominate.