Figure 6: Effect of fenofibrate (feno) and saxagliptin (saxa) on pathological changes in glomeruli. The section of 3 μM in thickness were made and stained with hematoxylin and eosin to assess the pathological changes of glomeruli using the light microscopy (40 X). The diabetic rats were noted to develop pathological changes in the glomeruli such as glomerular capillary size reduction and extracellular mesangial expansion as compared to normal rats. The concurrent administration of fenofibrate and saxagliptin markedly reduced the pathological changes in glomeruli by improving the glomerular capillary size and reducing the mesangial expansion as compared to treatment with either drug alone or lisinopril.