| Hypothesis base on previous publications of ‘Photoluminescence of Bioceramic Materials’(PLB) |
Possible mechanism of PLB to reduce hyperglycemia |
Reference number |
| Molecular diffusion |
Through weaken the hydrogen bonds between water molecules. Thus, the changes in the physical properties of water may promote the diffusion of glucose across cell membrane into intracellular space |
[19-21] |
| Calcium dependent nitric oxide enhancement |
Bioceramic irradiation promotes nitric oxide (NO) enhancement through calcium-dependent nitric oxide synthetase, which is beneficial for glucose metabolism. |
[8, 9] |
| Suppression of oxidative stress |
Oxidative stress lead to abnormal changes in intracellular signaling and result in chronic inflammation and insulin resistance, and then increase risk of hyperglycemia. PLB was proved to suppress oxidative stress. |
[10-14] |
| Autonomous nervous system regulation(ANS) |
Since excess stimulation sympathetic nervous system activity is associated with hyperglycemia. PLB enhanced parasympathetic nervous system and counteract sympathetic nervous system activity, suppose to help ameliorate hyperglycemia |
[22-24] |
