Figure 7: Fatty acid synthesis
This cytoplasmic anabolic reaction happens when the concentration of acetyl- CoA (the intermediate of glucose degradation pathway) is high. This means that in high consumption of carbohydrates and excess amount of energy in the body, some part of acetyl-CoA is converted to FAs for storage in the form of TAG. Insulin, that is the main hormone of pancreatic beta cells and is released during feeding state, stimulates this process. NADPH2 cofactor (product of the pentose phosphate pathway) is required in this process.